Journal
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
Volume 98, Issue -, Pages 12-23Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.critrevonc.2015.10.003
Keywords
Cancer; MicroRNAs; Oncogenes; Patents; Therapeutics; Tumor suppressors
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Funding
- Department of Biotechnology (DBT), Government of India [BT/PR3642/AGR/36/709/2011]
- Jaypee Institute of Information Technology
- Department of Biotechnology, Government of India
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MicroRNAs (miRNAs), a highly conserved class of tissue specific, small non-protein coding RNAs maintain cell homeostasis by negative gene regulation. Proper controlling of miRNA expression is required for a balanced physiological environment, as these small molecules influence almost every genetic pathway from cell cycle checkpoint, cell proliferation to apoptosis, with a wide range of target genes. Deregulation in miRNAs expression correlates with various cancers by acting as tumor suppressors and oncogenes. Although promising therapies exist to control tumor development and progression, there is a lack of efficient diagnostic and therapeutic approaches for delineating various types of cancer. The molecularly different tumors can be differentiated by specific miRNA profiling as their phenotypic signatures, which can hence be exploited to surmount the diagnostic and therapeutic challenges. Present review discusses the involvement of miRNAs in oncogenesis with the analysis of patented research available on miRNAs. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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