Journal
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
Volume 99, Issue -, Pages 13-36Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.critrevonc.2015.12.001
Keywords
CINV; Emesis; HRQoL; Direct cost; Indirect cost
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Funding
- Helsinn Group
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Background: Chemotherapy-induced nausea and vomiting (CINV) is a particularly distressing event for oncology patients. This review aims at analyzing the impact of CINV on Health-Related Quality of Life (QoL) and on the use of healthcare resources. Methods: A systematic search was conducted according to the PRISMA statement on MEDLINE, EMBASE and NHS EED. Results: Sixty-seven studies were included in the final selection. Despite the availability of numerous treatment options, CINV was found to have a strong impact on HRQoL of patients. Direct costs are particularly affected, but this result could be due to scarcity of studies assessing indirect costs. Conclusions: Evidence supports the notion that CINV continues to have a negative impact on HRQoL of patients, even for those receiving moderately emetic chemotherapy. Further studies need also to collect data on the cost of CINV, particularly indirect costs, to ensure that decisions on use of healthcare resources are better supported. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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