4.4 Review

Magnetic resonance spectroscopy in the rodent brain: Experts' consensus recommendations

Journal

NMR IN BIOMEDICINE
Volume 34, Issue 5, Pages -

Publisher

WILEY
DOI: 10.1002/nbm.4325

Keywords

anesthesia; brain metabolism; consensus review; dynamic MRS; neurochemical profile; preclinical MRS

Funding

  1. National Institutes of Health (NIH) [AG062677 NS100620, NS080816, AG063911, BTRC P41 EB027061 P30 NS076408]
  2. Swiss National Science Foundation (SNF) [310030_173222]
  3. Swiss National Science Foundation (SNF) [310030_173222] Funding Source: Swiss National Science Foundation (SNF)

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In vivo MRS is a non-invasive measurement technique used in humans and animal models to study metabolite concentrations, metabolic rates, and modifications. In preclinical studies, rodent models are used to study brain metabolism, providing additional biochemical information compared to clinical studies. High-field preclinical MRS has its own properties and technical limitations.
In vivo MRS is a non-invasive measurement technique used not only in humans, but also in animal models using high-field magnets. MRS enables the measurement of metabolite concentrations as well as metabolic rates and their modifications in healthy animals and disease models. Such data open the way to a deeper understanding of the underlying biochemistry, related disturbances and mechanisms taking place during or prior to symptoms and tissue changes. In this work, we focus on the main preclinical(1)H,P-31 and(13)C MRS approaches to study brain metabolism in rodent models, with the aim of providing general experts' consensus recommendations (animal models, anesthesia, data acquisition protocols). An overview of the main practical differences in preclinical compared with clinical MRS studies is presented, as well as the additional biochemical information that can be obtained in animal models in terms of metabolite concentrations and metabolic flux measurements. The properties of high-field preclinical MRS and the technical limitations are also described.

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