Journal
NEW ENGLAND JOURNAL OF MEDICINE
Volume 383, Issue 11, Pages 1068-1070Publisher
MASSACHUSETTS MEDICAL SOC
DOI: 10.1056/NEJMe2024545
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With a prevalence of 17.1 cases per 100,000 males, hemophilia A is the most frequent inherited disorder of blood coagulation.(1) After the adoption of prophylactic replacement therapy with factor VIII administered intravenously 3 or 4 times per week, patients' life expectancy has become very close to that of unaffected males.(1) Moreover, the occurrence of spontaneous bleeding and the development of musculoskeletal damage have been minimized. In addition, in the past decade, further impressive advances have occurred.(2,3) The arrival of factor VIII products with an extended plasma half-life has meant that intravenous injections that are needed to minimize bleeding can be . . .
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