Journal
CRITICAL REVIEWS IN BIOTECHNOLOGY
Volume 37, Issue 2, Pages 238-250Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/07388551.2016.1141392
Keywords
Biosensor; gold nanoparticles; synthesis; functionalization; protein; ligand; protein enrichment; mass spectrometry
Categories
Funding
- FCT/MEC [POCI-01-0145-FEDER-007679, UID /CTM /50011/2013]
- FEDER
- FCT (Fundacao para a Ciencia e a Tecnologia) [PTDC/EXPL/BBB-BEP/0317/2012]
- FEDER (COMPETE)
- FCT/MEC (PIDDAC) [CICECO-FCOMP-01-0124-FEDER-037271 (Pest-C/CTM/LA0011/2013), QOPNA-FCOMP-01-0124-FEDER-027554 (PEst-C/QUI/UI0062/2013), UID/IC/00051/2013, UID/BIM/04501/2013]
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In the last few years gold nanoparticles (AuNPs) became extremely interesting materials due to their enhanced optical, chemical and electrical properties. With the intention of taking advantage of those properties, the use of AuNPs has spread into a wide variety of areas such as physics, chemistry, biology, industry and medicine. More interestingly, their ability to form robust conjugates with biomolecules has given proteomics a new tool to improve aspects where the current methods to study proteins and their interactions in living cells cannot achieve the success required. In this review we present some of the current methods for AuNPs synthesis, the tailoring of their surface with ligands to improve stability and strategies to conjugate with biomolecules. Lastly, we also discuss their application in proteomic methods and recent developments in clinical diagnosis.
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