Journal
NEUROTOXICOLOGY
Volume 80, Issue -, Pages 1-11Publisher
ELSEVIER
DOI: 10.1016/j.neuro.2020.06.002
Keywords
Amyloid (A beta); Alzheimer's disease; Hippocampus; Neuro-inflammation; Memory impairment; BDNF
Categories
Funding
- Extramural Research Grant scheme by Science and Engineering Research Board, Department of Science and Technology [SERB/EMR/2015/001785]
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Alzheimer's disease (AD) is a chronic and progressive neurodegenerative disorder characterized by abnormal accumulation of extracellular beta-amyloid (A beta) plaques and neuronal damage. The present study investigated the effect of chronic intra-hippocampal agmatine administration on beta-Amyloid (A beta) induced memory impairment in mice. A beta(1-)(42) peptide injected mice demonstrated impairment of cognitive abilities evaluated as reference memory error and working memory error in radial arm maze (RAM) and decreased exploration time for novel object as well as recognition index in novel object recognition (NOR) test along with elevation in A beta(1-)(42) peptide, beta-Site APP cleaving enzyme 1 (BACE 1), microtubule-associated protein tau (MAPt), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha) and reduction in neprilysin and brain derived neurotrophic factor (BDNF) immunocontent within hippocampus and prefrontal cortex. Importantly, this was associated with a reduction in the agmatine levels following A beta(1-)(42) peptide administration. Chronic administration of agmatine from day 8-27, prevented the memory impairment in mice and normalized the neurochemical alteration within prefrontal cortex and hippocampus induced by A beta(1-42) peptide administration. However, it did not modulate the amyloid precursor protein and BACE expression. This study suggests that agmatine improves learning and memory impairment possibly through the down regulation of neuroinflammatory pathways in AD.
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