Journal
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
Volume 51, Issue 3, Pages 162-184Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/10409238.2016.1143913
Keywords
Cancer; cell cycle; cell division; mitosis; phosphatase; PP2A
Categories
Funding
- NIH [RO1 GM096060-01]
- NIH T32 [CA009135]
- Hartwell Foundation [133-PRJ24TF]
- NATIONAL CANCER INSTITUTE [T32CA009135] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM096060] Funding Source: NIH RePORTER
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Protein phosphatase 2A (PP2A) plays a critical multi-faceted role in the regulation of the cell cycle. It is known to dephosphorylate over 300 substrates involved in the cell cycle, regulating almost all major pathways and cell cycle checkpoints. PP2A is involved in such diverse processes by the formation of structurally distinct families of holoenzymes, which are regulated spatially and temporally by specific regulators. Here, we review the involvement of PP2A in the regulation of three cell signaling pathways: wnt, mTOR and MAP kinase, as well as the G1 -> S transition, DNA synthesis and mitotic initiation. These processes are all crucial for proper cell survival and proliferation and are often deregulated in cancer and other diseases.
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