Variety Is the Spice of Life: Positive and Negative Effects of Noise in Electrical Stimulation of the Nervous System

Noisy stimuli may hold the key for optimal electrical stimulation of the nervous system. Possible mechanisms of noise's impact upon neuronal function are discussed, including intracellular, extracellular, and systems-level mechanisms. Specifically, channel resonance, stochastic resonance, high conductance states, and network binding are investigated. These mechanisms are examined and possible directions of growth for the field are discussed, with examples of applications provided from the fields of deep brain stimulation or spinal cord injury. Together, this review highlights the theoretical basis and evidence base for the use of noise to enhance current stimulation paradigms of the nervous system.

Automated summary

This paper discusses the potential impact mechanisms of noise on neuronal function, including channel resonance, stochastic resonance, and high conductance states. It also explores how noise can enhance the theoretical and evidence base for electrical stimulation of the nervous system.