Journal
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
Volume 51, Issue 2, Pages 110-119Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/10409238.2016.1145185
Keywords
genomics; protein abundance; yeast; Fluorescence microscopy; protein localization; quantitative cell biology
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Funding
- Canadian Institutes of Health Research
- Canadian Cancer Society Research Institute
- Natural Sciences and Engineering Research Council of Canada
- Cancer Research Society
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Proteins directly carry out and regulate cellular functions. As a result, changes in protein levels within a cell directly influence cellular processes. Similarly, it is intuitive that the intracellular localization of proteins is a key component of their functionality. Optimal activity is achieved by a combination of protein concentration, co-compartmentalization with substrates, co-factors and regulators and sequestration from deleterious locales. The proteome within a cell is highly dynamic and changes in response to different environmental conditions. High-throughput microscopic analysis in the budding yeast Saccharomyces cerevisiae has afforded proteome-wide views of protein organization in living cells, and of how protein abundance and location is regulated and remodeled in response to stress.
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