Journal
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
Volume 51, Issue 6, Pages 440-451Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10409238.2016.1215407
Keywords
Aging; cancer; DNA repair; EXO1; mismatch repair; double-strand break repair; post-translational modification; telomere maintenance
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Funding
- Fru Astrid Thaysens Legat for Laegevidenskabelig Grundforskning [ALT 14/01]
- Arvid Nilssons Fond
- Fabrikant Ejner Willumsens Mindelegat
- Oda og Hans Svenningsens Fond [BOF-10109]
- Vissing fonden [54622]
- China Scholarship Council (CSC)
- Nordea-Fonden
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Exonuclease 1 (EXO1) is a multifunctional 5 3 exonuclease and a DNA structure-specific DNA endonuclease. EXO1 plays roles in DNA replication, DNA mismatch repair (MMR) and DNA double-stranded break repair (DSBR) in lower and higher eukaryotes and contributes to meiosis, immunoglobulin maturation, and micro-mediated end-joining in higher eukaryotes. In human cells, EXO1 is also thought to play a role in telomere maintenance. Mutations in the human EXO1 gene correlate with increased susceptibility to some cancers. This review summarizes recent studies on the enzymatic functions and biological roles of EXO1, its possible protective role against cancer and aging, and regulation of EXO1 by posttranslational modification.
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