Journal
NEURON
Volume 108, Issue 4, Pages 707-+Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2020.08.026
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Funding
- National Key Research and Development Program of China [2016YFA0501000]
- National Foundation of Natural Science of China [31471023, 31771113, 81821091, 91732000, 31800878, 31900736]
- Science and Technology Planning Project of Guangdong Province, China [2018B030331001]
- Fundamental Research Funds for the Central Universities, China [2018FZA7004]
- Fellowship of China National Postdoctoral Program for Innovative Talents, China [BX20200297]
- China Postdoctoral Science Foundation [2020M671695, 2020T130592]
- 111 project, China
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Glia are typically considered as supporting cells for neural development and synaptic transmission. Here, we report an active role of a glia in olfactory transduction. As a polymodal sensory neuron in C. elegans, the ASH neuron is previously known to detect multiple aversive odorants. We reveal that the AMsh glia, a sheath for multiple sensory neurons including ASH, cell-autonomously respond to aversive odorants via G-protein-coupled receptors (GPCRs) distinct from those in ASH. Upon activation, the AMsh glia suppress aversive odorant-triggered avoidance and promote olfactory adaptation by inhibiting the ASH neuron via GABA signaling. Thus, we propose a novel two-receptor model where the glia and sensory neuron jointly mediate adaptive olfaction. Our study reveals a non-canonical function of glial cells in olfactory transduction, which may provide new insights into the glia-like supporting cells in mammalian sensory procession.
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