Journal
NEURON
Volume 108, Issue 3, Pages 401-412Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2020.08.003
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Funding
- Wellcome Trust, United Kingdom [WT106964MA, 210567/Z/18/Z]
- Medical Research Council, United Kingdom [MR/T032553/1]
- National Institutes of Health, USA [2R01DC004290, 5P50DC000242-33]
- Action on Hearing Loss, United Kingdom
- Guarantors of Brain, United Kingdom
- Wellcome Trust [210567/Z/18/Z] Funding Source: Wellcome Trust
- MRC [MR/T032553/1] Funding Source: UKRI
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Epidemiological studies identify midlife hearing loss as an independent risk factor for dementia, estimated to account for 9% of cases. We evaluate candidate brain bases for this relationship. These bases include a com-mon pathology affecting the ascending auditory pathway and multimodal cortex, depletion of cognitive reserve due to an impoverished listening environment, and the occupation of cognitive resources when listening in difficult conditions. We also put forward an alternate mechanism, drawing on new insights into the role of the medial temporal lobe in auditory cognition. In particular, we consider how aberrant activity in the service of auditory pattern analysis, working memory, and object processing may interact with dementia pathology in people with hearing loss. We highlight how the effect of hearing interventions on dementia depends on the specific mechanism and suggest avenues for work at the molecular, neuronal, and systems levels to pin this down.
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