Journal
NEURON
Volume 108, Issue 4, Pages 691-+Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2020.08.013
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Funding
- National Research Foundation of Korea (NRF) [2017R1A5A2015391, 2014M3A7B4051596, 2017R1A2B3011098, 2017M3C7A1023471, 2015R1A3A2066619, 2013M3A9C4078145, 2020R1A4A1019009]
- Korea Health Technology R&D Project of the Korea Health Industry Development Institute [HI18C1664]
- International Collaborative R&D Program - Ministry of Trade, Industry and Energy [N0001720]
- General Research Program of the National Natural Science Foundation of China [31871087, 31671118]
- Brain Korea 21 PLUS
- Institute for Basic Science (IBS), Center for Cognition and Sociality [IBSR001-D2]
- National Research Foundation of Korea [2015R1A3A2066619, 5120201413813, 2020R1A4A1019009, 2017M3C7A1023471, 2014M3A7B4051596, 2017R1A2B3011098, 2013M3A9C4078145] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Sensory discrimination is essential for survival. However, how sensory information is finely controlled in the brain is not well defined. Here, we show that astrocytes control tactile acuity via tonic inhibition in the thalamus. Mechanistically, diamine oxidase (DAO) and the subsequent aldehyde dehydrogenase 1a1 (Aldh1a1) convert putrescine into GABA, which is released via Best1 The GABA from astrocytes inhibits synaptically evoked firing at the lemniscal synapses to fine-tune the dynamic range of the stimulation-response relationship, the precision of spike timing, and tactile discrimination. Our findings reveal a novel role of astrocytes in the control of sensory acuity through tonic GABA release.
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