Journal
NEUROIMAGE
Volume 220, Issue -, Pages -Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2020.117079
Keywords
Designer receptors exclusively activated by designer drugs; Magnetic resonance imaging; Clozapine; Clozapine-N-Oxide; Striatum; Drd1-receptor-expressing striatal projection neurons
Funding
- Inserm
- Sorbonne University
- Fondation pour la Recherche Medicale (FRM) [DPA20140629798]
- ANR [ANR-16-CE16-0018]
- Fondation de France [00086313]
- Federation pour la recherche sur le cerveau (FRC)
- Rotary Espoir en Tete
- DIM Cerveau et Pensee Region Ile-de-France
- Uehara Memorial Foundation [201430033]
- Fyssen Foundation fellowship
- Idex Paris-Saclay
- Agence Nationale de la Recherche (ANR) [ANR-16-CE16-0018] Funding Source: Agence Nationale de la Recherche (ANR)
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Abnormal structural and functional connectivity in the striatum during neurological disorders has been reported using functional magnetic resonance imaging (fMRI), although the effects of cell-type specific neuronal stimulation on fMRI and related behavioral alterations are not well understood. In this study, we combined DREADD technology with fMRI (chemo-fMRI) to investigate alterations of spontaneous neuronal activity. These were induced by the unilateral activation of dopamine D1 receptor-expressing neurons (D1-neurons) in the mouse dorsal striatum (DS). After clozapine (CLZ) stimulation of the excitatory DREADD expressed in Dl-neurons, the fractional amplitude of low frequency fluctuations (fALFF) increased bilaterally in the medial thalamus, nucleus accumbens and cortex. In addition, we found that the gamma-band of local field potentials was increased in the stimulated DS and cortex bilaterally. These results provide insights for better interpretation of cell type-specific activity changes in fMRI.
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