4.5 Review

Mechanisms of NLRP3 Inflammasome Activation: Its Role in the Treatment of Alzheimer's Disease

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

MCC950 directly targets the NLRP3 ATP- hydrolysis motif for inflammasome inhibition

Rebecca C. Coll et al.

NATURE CHEMICAL BIOLOGY (2019)

Article Biochemistry & Molecular Biology

MCC950 closes the active conformation of NLRP3 to an inactive state

Ana Tapia-Abelian et al.

NATURE CHEMICAL BIOLOGY (2019)

Article Multidisciplinary Sciences

NLRP3 inflammasome activation drives tau pathology

Christina Ising et al.

NATURE (2019)

Review Biology

The NLRP3 inflammasome: a new player in neurological diseases

Elif Eren et al.

TURKISH JOURNAL OF BIOLOGY (2019)

Review Clinical Neurology

Neuroinflammatory responses in Alzheimer's disease

Cira Dansokho et al.

JOURNAL OF NEURAL TRANSMISSION (2018)

Review Medicine, Research & Experimental

Innate Immunity and Neurodegeneration

Larisa I. Labzin et al.

ANNUAL REVIEW OF MEDICINE, VOL 69 (2018)

Review Immunology

Inflammation in CNS neurodegenerative diseases

Jodie Stephenson et al.

IMMUNOLOGY (2018)

Review Immunology

NADPH oxidases and ROS signaling in the gastrointestinal tract

Gabriella Aviello et al.

MUCOSAL IMMUNOLOGY (2018)

Review Cell Biology

Danger-associated molecular patterns in Alzheimer's disease

Carmen Venegas et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2017)

Article Immunology

Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders

Hua Jiang et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2017)

Article Biochemistry & Molecular Biology

Autophagy and inflammasomes

James Harris et al.

MOLECULAR IMMUNOLOGY (2017)

Article Multidisciplinary Sciences

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer's disease

Carmen Venegas et al.

NATURE (2017)

Article Clinical Neurology

Inflammasome activation and innate immunity in Alzheimer's disease

Michael T. Heneka

BRAIN PATHOLOGY (2017)

Article Cell Biology

Impaired autophagy in macrophages promotes inflammatory eye disease

Andrea Santeford et al.

AUTOPHAGY (2016)

Article Immunology

Microglial toll-like receptors and Alzheimer's disease

Fan Su et al.

BRAIN BEHAVIOR AND IMMUNITY (2016)

Article Biochemistry & Molecular Biology

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

Zhenyu Zhong et al.

Article Multidisciplinary Sciences

Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer's disease in rodent models

Michael J. D. Daniels et al.

NATURE COMMUNICATIONS (2016)

Article Immunology

Multiple Cathepsins Promote Pro-IL-1β Synthesis and NLRP3-Mediated IL-1β Activation

Gregory M. Orlowski et al.

JOURNAL OF IMMUNOLOGY (2015)

Review Medicine, Research & Experimental

NALP3 inflammasome activation in protein misfolding diseases

Fushan Shi et al.

LIFE SCIENCES (2015)

Article Biochemistry & Molecular Biology

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

Rebecca C. Coll et al.

NATURE MEDICINE (2015)

Article Neurosciences

Autophagy in Alzheimer's disease

Ameneh Zare-shahabadi et al.

REVIEWS IN THE NEUROSCIENCES (2015)

Review Pharmacology & Pharmacy

Anti-inflammatory agents to treat or prevent type 2 diabetes, metabolic syndrome and cardiovascular disease

Nathalie Esser et al.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2015)

Article Biochemistry & Molecular Biology

Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes

Alvin Lu et al.

Review Biochemistry & Molecular Biology

Mechanisms and Functions of Inflammasomes

Mohamed Lamkanfi et al.

Article Multidisciplinary Sciences

IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation

Keng-Mean Lin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Editorial Material Cell Biology

Love and death: microglia, NLRP3 and the Alzheimer's brain

Tobias Goldmann et al.

CELL RESEARCH (2013)

Article Biochemistry & Molecular Biology

Deubiquitinases Regulate the Activity of Caspase-1 and Interleukin-1β Secretion via Assembly of the Inflammasome

Gloria Lopez-Castejon et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Immunology

Cutting Edge: TLR Signaling Licenses IRAK1 for Rapid Activation of the NLRP3 Inflammasome

Teresa Fernandes-Alnemri et al.

JOURNAL OF IMMUNOLOGY (2013)

Article Biochemistry & Molecular Biology

Deubiquitination of NLRP3 by BRCC3 Critically Regulates Inflammasome Activity

Benedicte F. Py et al.

MOLECULAR CELL (2013)

Article Multidisciplinary Sciences

NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice

Michael T. Heneka et al.

NATURE (2013)

Article Biochemistry & Molecular Biology

Non-transcriptional Priming and Deubiquitination Regulate NLRP3 Inflammasome Activation

Christine Juliana et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Review Cell Biology

Redox control of NLRP3 inflammasome activation in health and disease

Anna Rubartelli

JOURNAL OF LEUKOCYTE BIOLOGY (2012)

Review Chemistry, Medicinal

Interleukin-1 Receptor Antagonist: A New Therapy for Type 2 Diabetes Mellitus

Muhammad Sajid Hamid Akash et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2012)

Review Biotechnology & Applied Microbiology

Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases

Charles A. Dinarello et al.

NATURE REVIEWS DRUG DISCOVERY (2012)

Article Multidisciplinary Sciences

A role for mitochondria in NLRP3 inflammasome activation

Rongbin Zhou et al.

NATURE (2011)

Review Neurosciences

Heterogeneity of CNS myeloid cells and their roles in neurodegeneration

Marco Prinz et al.

NATURE NEUROSCIENCE (2011)

Review Neurosciences

APP Transgenic Mice: Their Use and Limitations

Claudia Balducci et al.

NEUROMOLECULAR MEDICINE (2011)

Review Biochemistry & Molecular Biology

Disease-associated amyloid and misfolded protein aggregates activate the inflammasome

Seth L. Masters et al.

TRENDS IN MOLECULAR MEDICINE (2011)

Review Biochemistry & Molecular Biology

The Inflammasomes

Kate Schroder et al.

Article Immunology

Molecular Mechanism of NLRP3 Inflammasome Activation

Chengcheng Jin et al.

JOURNAL OF CLINICAL IMMUNOLOGY (2010)

Review Neurosciences

Inflammation, microglia, and alzheimer's disease

Brent Cameron et al.

NEUROBIOLOGY OF DISEASE (2010)

Review Immunology

The Inflammasomes: Guardians of the Body

Fablo Martinon et al.

ANNUAL REVIEW OF IMMUNOLOGY (2009)

Review Biochemistry & Molecular Biology

Mitochondria and reactive oxygen species

Alicia J. Kowaltowski et al.

FREE RADICAL BIOLOGY AND MEDICINE (2009)

Review Biochemistry & Molecular Biology

Nox proteins in signal transduction

David I. Brown et al.

FREE RADICAL BIOLOGY AND MEDICINE (2009)

Article Infectious Diseases

Autophagy and the Immune Response to TB

J. Harris et al.

TRANSBOUNDARY AND EMERGING DISEASES (2009)

Article Neurosciences

Microglial dysfunction and defective β-amyloid clearance pathways in aging Alzheimer's disease mice

Suzanne E. Hickman et al.

JOURNAL OF NEUROSCIENCE (2008)

Article Multidisciplinary Sciences

Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer's disease

Melanie Meyer-Luehmann et al.

NATURE (2008)

Article Multidisciplinary Sciences

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

Tatsuya Saitoh et al.

NATURE (2008)

Article Immunology

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

Annett Halle et al.

NATURE IMMUNOLOGY (2008)

Article Multidisciplinary Sciences

Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica

Catherine Dostert et al.

SCIENCE (2008)

Review Immunology

COPs and POPs: Modulators of inflammasome activity

Christian Stehlik et al.

JOURNAL OF IMMUNOLOGY (2007)

Review Immunology

Intracellular NOD-like receptors in host Defense and disease

Thirumala-Devi Kanneganti et al.

IMMUNITY (2007)

Article Biochemistry & Molecular Biology

Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration

V. Petrilli et al.

CELL DEATH AND DIFFERENTIATION (2007)

Review Cell Biology

Caspase-1 inflammasomes in infection and inflammation

Mohamed Lamkanfi et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2007)

Article Multidisciplinary Sciences

Cryopyrin/NALP3 binds ATP/dATP, is an ATPase, and requires ATP binding to mediate inflammatory signaling

Joseph A. Duncan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Immunology

Pyrin-only protein 2 modulates NFκB and disrupts ASC:CLR interactions

Felipe Bedoya et al.

JOURNAL OF IMMUNOLOGY (2007)

Article Immunology

Cellular pyrin domain-only protein 2 is a candidate regulator of inflammasome activation

Andrea Dorfleutner et al.

INFECTION AND IMMUNITY (2007)

Review Medicine, General & Internal

Alzheimer's disease

Kaj Blennow et al.

LANCET (2006)

Article Multidisciplinary Sciences

The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1β production

Jae Jin Chae et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Multidisciplinary Sciences

Cryopyrin activates the inflammasome in response to toxins and ATP

S Mariathasan et al.

NATURE (2006)

Article Multidisciplinary Sciences

Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

S Mariathasan et al.

NATURE (2004)

Article Immunology

CD36 mediates the innate host response to β-amyloid

JB El Khoury et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2003)