Journal
NEUROBIOLOGY OF AGING
Volume 94, Issue -, Pages 250-264Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2020.06.011
Keywords
Alzheimer's disease; Anosognosia; Neural-correlates; Neuroimaging; Systematic review
Categories
Funding
- Wellcome Clinical Research Career Development Fellowship [214547/Z/18/Z]
- Marie Curie Chair's Grant [509537]
- Wellcome Trust [214547/Z/18/Z] Funding Source: Wellcome Trust
Ask authors/readers for more resources
Awareness of one's own cognitive processes (metacognition) or of one's own illness or deficits (anosognosia) can be impaired in people with Alzheimer's disease (AD). The neural correlates of anosognosia within AD remain inconclusive. Understanding anosognosia is of importance because of its impact on carer burden and increased institutionalization. A systematic review of structural and functional neuroimaging studies was conducted to identify specific brain regions associated with anosognosia within AD. Thirty-two studies were included in the systematic review. Reduced gray matter density, cerebral blood flow, and hypometabolism in 8 key regions were significantly associated with increased anosognosia scores in people with AD. The most frequently associated regions were the inferior frontal gyrus, anterior cingulate cortex, and medial temporal lobe. Other key regions include the superior frontal gyrus, medial frontal gyrus, orbitofrontal cortex, posterior cingulate cortex, and the insula. Identifying brain regions associated with anosognosia can aid understanding and identification of anosognosia in people with AD and potentially facilitate improvements in care. (C) 2020 The Authors. Published by Elsevier Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available