Journal
NEURAL COMPUTING & APPLICATIONS
Volume -, Issue -, Pages -Publisher
SPRINGER LONDON LTD
DOI: 10.1007/s00521-020-05432-2
Keywords
Type 1 diabetes; Continuous glucose monitoring; k-medoids clustering; Abnormality detection
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Funding
- National Natural Science Foundation of China [61903071, 61973067]
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As continuous glucose monitoring (CGM) systems provide critical feedback information of blood glucose concentration to the artificial pancreas for patients with type 1 diabetes (T1D), faults in CGM may seriously affect the computation of insulin infusion rates which can lead to fatal consequences accompany with hypoglycemia or hyperglycemia. In the present work, the k-medoids clustering algorithm is modified by calculating cluster number with a Bayesian Information Criterion (BIC)-based cost function and the SAC (SSE-ASW Criterion) evaluation coefficient which considers both SSE (Sum of Square due to Error) and ASW (Average Silhouette Width) criteria. Then, the modified k-medoids clustering algorithm is proposed to detect sensor failures online with CGM measurements. Different from the qualitative model-based methods and quantitative model-based methods, sufficient clean data are the only requirement of the proposed method. During online monitoring, the new glycemic variability is then tracked against predefined confidence limits during training period to indicate abnormality. The feasibility of the proposed method is successfully assessed using CGM data collected from the UVa/Padova metabolic simulator.
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