Journal
NATURE REVIEWS NEUROSCIENCE
Volume 21, Issue 10, Pages 551-564Publisher
NATURE RESEARCH
DOI: 10.1038/s41583-020-0361-8
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Funding
- Russian Science Foundation [20-14-00241]
- Chica and Heinz Schaller Research Foundation
- Brain & Behaviour Research Foundation via a National Alliance for Research on Schizophrenia & Depression (NARSAD) Young Investigator Award
- Deutsche Forschungsgemeinschaft (DFG) [SFB1134-B01, SFB1158-A09, FOR2289-P8, SFB1089 B03, SPP1757 HE6949/1, FOR2795, HE6949/3]
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Although not electrically excitable, astrocytes display a complex repertoire of intracellular Ca(2+)signalling. Semyanov, Henneberger and Agarwal describe experimental preparations and methods for studying Ca(2+)activity in astrocytes, their limitations and the ongoing technical and conceptual challenges in the interpretation of astrocytic Ca(2+)events and their spatio-temporal patterns. Astrocytes functionally interact with neurons and with other brain cells. Although not electrically excitable, astrocytes display a complex repertoire of intracellular Ca(2+)signalling that evolves in space and time within single astrocytes and across astrocytic networks. Decoding the physiological meaning of these dynamic changes in astrocytic Ca(2+)activity has remained a major challenge. This Review describes experimental preparations and methods for recording and studying Ca(2+)activity in astrocytes, focusing on the analysis of Ca(2+)signalling events in single astrocytes and in astrocytic networks. The limitations of existing experimental approaches and ongoing technical and conceptual challenges in the interpretation of astrocytic Ca(2+)events and their spatio-temporal patterns are also discussed.
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