Journal
NATURE REVIEWS CARDIOLOGY
Volume 18, Issue 2, Pages 75-91Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41569-020-00445-9
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Funding
- NIH [R01 HL149134, R01 HL83359]
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Ambulatory monitoring is becoming increasingly important in cardiovascular care, but is limited by the unpredictability of cardiovascular events. Introduction of novel physiological biosignals may increase the frequency of abnormality detection, allowing for expert-level automated diagnosis, but raises concerns regarding accuracy and actionability. Utilizing analytical methods like machine learning may improve the accuracy and actionability of diagnoses, ultimately facilitating near-real-time diagnosis and therapy. Regulatory and ethical issues are recognized, but further technical and ethical challenges remain.
Ambulatory monitoring is increasingly important for cardiovascular care but is often limited by the unpredictability of cardiovascular events, the intermittent nature of ambulatory monitors and the variable clinical significance of recorded data in patients. Technological advances in computing have led to the introduction of novel physiological biosignals that can increase the frequency at which abnormalities in cardiovascular parameters can be detected, making expert-level, automated diagnosis a reality. However, use of these biosignals for diagnosis also raises numerous concerns related to accuracy and actionability within clinical guidelines, in addition to medico-legal and ethical issues. Analytical methods such as machine learning can potentially increase the accuracy and improve the actionability of device-based diagnoses. Coupled with interoperability of data to widen access to all stakeholders, seamless connectivity (an internet of things) and maintenance of anonymity, this approach could ultimately facilitate near-real-time diagnosis and therapy. These tools are increasingly recognized by regulatory agencies and professional medical societies, but several technical and ethical issues remain. In this Review, we describe the current state of cardiovascular monitoring along the continuum from biosignal acquisition to the identification of novel biosensors and the development of analytical techniques and ultimately to regulatory and ethical issues. Furthermore, we outline new paradigms for cardiovascular monitoring.
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