Journal
NATURE NEUROSCIENCE
Volume 23, Issue 11, Pages 1388-+Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41593-020-00712-5
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Funding
- NIH [NINDS R01NS103226]
- a P30 Core Center Grant [NINDS NS072030]
- Iljou Foundation
- Simons Collaborative on the Global Brain
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In the basal ganglia (BG), anatomically segregated and topographically organized feedforward circuits are thought to modulate multiple behaviors in parallel. Although topographically arranged BG circuits have been described, the extent to which these relationships are maintained across the BG output nuclei and in downstream targets is unclear. Here, using focaltrans-synaptic anterograde tracing, we show that the motor-action-related topographical organization of the striatum is preserved in all BG output nuclei. The topography is also maintained downstream of the BG and in multiple parallel closed loops that provide striatal input. Furthermore, focal activation of two distinct striatal regions induces either licking or turning, consistent with their respective anatomical targets of projection outside of the BG. Our results confirm the parallel model of BG function and suggest that the integration and competition of information relating to different behavior occur largely outside of the BG. This study demonstrates that basal ganglia functional topography is maintained across and downstream of its output nuclei, and in closed loops. Focal stimulation of distinct striatal subregions induces distinct action, supporting a model of parallel behavioral control.
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