Journal
NATURE MEDICINE
Volume 26, Issue 9, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41591-020-1012-3
Keywords
-
Funding
- UK Medical Research Council [MC_UU_12015/1, MC_UU_12015/3]
- National Health and Medical Research Council of Australia [1142685]
- Cambridge Trust
- St Catharine's College
- National Health and Medical Research Council of Australia [1142685] Funding Source: NHMRC
- MRC [MC_UU_00006/4, MC_UU_12015/1, MC_UU_12015/3] Funding Source: UKRI
Ask authors/readers for more resources
Use of wearable devices that monitor physical activity is projected to increase more than fivefold per half-decade(1). We investigated how device-based physical activity energy expenditure (PAEE) and different intensity profiles were associated with all-cause mortality. We used a network harmonization approach to map dominant-wrist acceleration to PAEE in 96,476 UK Biobank participants (mean age 62 years, 56% female). We also calculated the fraction of PAEE accumulated from moderate-to-vigorous-intensity physical activity (MVPA). Over the median 3.1-year follow-up period (302,526 person-years), 732 deaths were recorded. Higher PAEE was associated with a lower hazard of all-cause mortality for a constant fraction of MVPA (for example, 21% (95% confidence interval 4-35%) lower hazard for 20 versus 15 kJ kg(-1) d(-1)PAEE with 10% from MVPA). Similarly, a higher MVPA fraction was associated with a lower hazard when PAEE remained constant (for example, 30% (8-47%) lower hazard when 20% versus 10% of a fixed 15 kJ kg(-1) d(-1)PAEE volume was from MVPA). Our results show that higher volumes of PAEE are associated with reduced mortality rates, and achieving the same volume through higher-intensity activity is associated with greater reductions than through lower-intensity activity. The linkage of device-measured activity to energy expenditure creates a framework for using wearables for personalized prevention. Analysis of UK Biobank participants with wearable physical activity monitors demonstrates that high-volume physical activity and high-intensity activity are associated with reduced mortality.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available