Journal
NATURE CHEMICAL BIOLOGY
Volume 16, Issue 12, Pages 1420-+Publisher
NATURE RESEARCH
DOI: 10.1038/s41589-020-00658-6
Keywords
-
Categories
Funding
- Max Planck Society
- Deutsche Forschungsgemeinschaft (DFG Collaborative Research Center 1127 ChemBioSys)
- Natural Resources Institute, University of Greenwich by the Bill and Melinda Gates Foundation [OPP1058938]
Ask authors/readers for more resources
The metabolic adaptations by which phloem-feeding insects counteract plant defense compounds are poorly known. Two-component plant defenses, such as glucosinolates, consist of a glucosylated protoxin that is activated by a glycoside hydrolase upon plant damage. Phloem-feeding herbivores are not generally believed to be negatively impacted by two-component defenses due to their slender piercing-sucking mouthparts, which minimize plant damage. However, here we document that glucosinolates are indeed activated during feeding by the whiteflyBemisia tabaci. This phloem feeder was also found to detoxify the majority of the glucosinolates it ingests by the stereoselective addition of glucose moieties, which prevents hydrolytic activation of these defense compounds. Glucosylation of glucosinolates inB. tabaciwas accomplished via a transglucosidation mechanism, and two glycoside hydrolase family 13 (GH13) enzymes were shown to catalyze these reactions. This detoxification reaction was also found in a range of other phloem-feeding herbivores.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available