Journal
NATURE BIOTECHNOLOGY
Volume 39, Issue 2, Pages -Publisher
NATURE RESEARCH
DOI: 10.1038/s41587-020-0679-9
Keywords
-
Categories
Funding
- NIH
- NSF
- Gatsby Foundation
- Fresenius Foundation
- Wiegers Foundation
- Grosfeld Foundation
- NOMIS Foundation
- Walter V. and Idun Berry Postdoctoral Fellowship
- NARSAD Young Investigator Grant
- University of Minnesota's MnDRIVE (Minnesota's Discovery, Research and Innovation Economy) initiative [NS94668]
- [K99 DA050662]
- [F32 NS106764]
- [R01 NS112518]
- [R01 NS104071]
Ask authors/readers for more resources
Achieving precise control over specific neural circuits in the deep brain without surgery is possible using ChRmine, enabling behavioral modulation and optogenetic control of neural activity at unprecedented depths.
Achieving temporally precise, noninvasive control over specific neural cell types in the deep brain would advance the study of nervous system function. Here we use the potent channelrhodopsin ChRmine to achieve transcranial photoactivation of defined neural circuits, including midbrain and brainstem structures, at unprecedented depths of up to 7 mm with millisecond precision. Using systemic viral delivery of ChRmine, we demonstrate behavioral modulation without surgery, enabling implant-free deep brain optogenetics. Optogenetic control of neural activity in the deep brain is achieved without intracranial surgery using ChRmine.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available