Journal
NATURAL PRODUCT RESEARCH
Volume 36, Issue 9, Pages 2329-2335Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2020.1834547
Keywords
Cornus officinalis; secoiridoid glycosides; neuroprotective activity
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Funding
- Scientific Research Common Program of Beijing Municipal Commission of Education [KM201911417014]
- Premium Funding Project for Academic Human Resources Development in Beijing Union University [BPHR2019DZ02]
- Key projects of the Beijing Natural Sciences Foundation
- Beijing Municipal Education Committee [KZ201811417049]
- Innovation Platform for the Development and Construction of Special Project of Key Laboratory for Tibet Plateau Phytochemistry of Qinghai Province [2019-ZJ-Y19]
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This study isolated and characterized five new secoiridoid glycosides from the fruits of Cornus officinalis. One of these compounds showed a neuroprotective effect against H2O2-induced cell damage in preliminary assays.
Five new secoiridoid glycosides, cornusphenosides E-I (1-5), were isolated and characterized from an active fraction of ethanol extract of the fruits ofCornus officinalis. Their structures were determined by extensive spectroscopic data analysis, including 2 D NMR and HRESIMS experiments. In the preliminary assay, compound5(when evaluated at 10 mu M) showed the neuroprotective effect against H2O2-induced SH-SY5Y cell damage.
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