A new coumarin isolated from the roots ofHeracleum dissectumLedeb

A new coumarin named (9 R, 10 R)-9, 10-dihydro-10-hydroxy-9-methoxy-bergapten (1) and 13 known compounds (2-14) were isolated from the roots ofHeracleum dissectumLedeb., in which compounds (2-13) were obtained fromH. dissectumfor the first time. Their structures were illuminated by HR-ESI MS, 1 D and 2 D NMR, optical rotation and comparison with literatures. All compounds were evaluated against hepatocellular carcinoma HepG2 cell lines and the results showed that candinol C (8) had moderate cytotoxic activity against HepG2 cells with IC(50)value at 57.6 +/- 1.1 mu M.

Automated summary

A new coumarin and 13 known compounds were isolated from the roots of Heracleum dissectum. These compounds showed varying degrees of cytotoxic activity against hepatocellular carcinoma HepG2 cell lines.