Journal
NANO TODAY
Volume 34, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.nantod.2020.100910
Keywords
Nanoscale coordination polymer; Photothermal therapy; Nucleus targeting; Near-infrared; Heptamethine cyanine
Categories
Funding
- National Key RAMP
- D Program of China [2018YFC0910601]
- Natural Science Foundation of China [81871411, 32011530115]
- Youth Innovation Promotion Association Foundation of CAS [2017340]
- Key RAMP
- D Program of Zhejiang Province [2020003110]
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Effective photothermal therapy (PTT) under low temperature (< 50 degrees C) and power density (< 0.4 W/cm(2)) avoiding the damage of skin and normal organs. Here, we report a novel heptamethine cyanine dye-based nanoscale coordination polymer (NCP), Hf-HI-4COOH, as an exceptionally effective photosensitizer for nucleus-targeting low temperature PTT. Hf-HI-4COOH shows strong near-infrared absorption and high photothermal conversion efficiency (39.51 %). Further, it exhibits intrinsic nucleus-targeting property and cell inhibition under low power density in vitro. Moreover, the long blood circulation, high tumor accumulation, and nucleus-targeting contribute to significant inhibition of breast tumors in tumor-bearing mice under low temperature (48 degrees C) and power density (0.3 W/cm(2)) without obvious toxicity. In general, we establish a nucleus-targeting Hf-HI-4COOH for enhanced PTT with low temperature and power density. (C) 2020 Elsevier Ltd. All rights reserved.
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