Journal
NANO RESEARCH
Volume 13, Issue 12, Pages 3268-3277Publisher
TSINGHUA UNIV PRESS
DOI: 10.1007/s12274-020-3000-9
Keywords
radiotherapy; second near-infrared window (NIR-II); fluorescence imaging; photoacoustic imaging; plasmonic gold nanovesicle
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Funding
- National Natural Science Foundation of China [21635002, 21874024]
- joint research projects of Health and Education Commission of Fujian Province [2019-WJ-20]
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Multimodal imaging in the second near-infrared window (NIR-II) guided cancer therapy is a highly precise and efficient cancer theranostic strategy. However, it is still a challenge to develop activated NIR-II optical imaging and therapy agents. In this study, we develop a pH-responsive hybrid plasmonic-fluorescent vesicle by self-assembly of amphiphilic plasmonic nanogapped gold nanorod (AuNNR) and fluorescent down-conversion nanoparticles (DCNP) (AuNNR-DCNP Ve), showing remarkable and activated NIR-II fluorescence (FL)/NIR-II photoacoustic (PA) imaging performances. The hybrid vesicle also exhibited superior loading capacity of doxorubicin as a superior drug carrier and efficient radiosensitizer for X-ray-induced radiotherapy. Interestingly, the accumulated hybrid AuNNR-DCNP Ve in the tumor resulted in a recovery of NIR-II FL imaging signal and a variation in NIR-II PA imaging signal. Dual activated NIR-II PA and FL imaging of the hybrid vesicle could trace drug release and precisely guided cancer radiotherapy to ultimately reduce the side effects to healthy tissue.
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