Journal
NANO RESEARCH
Volume 14, Issue 3, Pages 879-886Publisher
TSINGHUA UNIV PRESS
DOI: 10.1007/s12274-020-3130-0
Keywords
two-dimensional (2-D) nanosheets; assembled heterostructure; interface; flexible biosensor; real-time monitoring
Categories
Funding
- National Natural Science Foundation of China [21972102, 21705115, 21605110]
- Natural Science Foundation of Jiangsu Province of China [BK20170378]
- Natural Science Research Foundation of Jiangsu Higher Education Institutions [17KJB150036]
- Jiangsu Laboratory of Biological and Chemical Sensing and Biochip
- Jiangsu Innovation and Entrepreneurship Plan
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This study presents a flexible Mn-3(PO4)(2)/MXene heterostructured biomimetic enzyme for real-time monitoring of superoxide anion, exhibiting excellent flexibility, high sensitivity, and wide detection range toward O-2(center dot-).
It is critical for fabricating flexible biosensors with both high sensitivity and good selectivity to realize real-time monitoring superoxide anion (O-2(center dot-)), a specific reactive oxygen species that plays critical roles in various biological processes. This work delicately designs a Mn-3(PO4)(2)/MXene heterostructured biomimetic enzyme by assembling two-dimensional (2-D) Mn-3(PO4)(2) nanosheets with biomimetic activity and 2-D MXene nanosheets with high conductivity and abundant functional groups. The 2-D nature of the two components with strong interfacial interaction synergistically enables the heterostructure an excellent flexibility with retained 100% of the response when to reach a bending angle up to 180 degrees, and 96% of the response after 100 bending/relaxing cycles. It is found that the surface charge state of the heterostructure promotes the adsorption of O-2(center dot-), while the high-energy active site improves electrochemical oxidation of O-2(center dot-). The Mn-3(PO4)(2)/MXene as a sensing platform towards O-2(center dot-) achieves a high sensitivity of 64.93 mu A.mu M-1.cm(-2), a wide detection range of 5.75 nM to 25.93 mu M, and a low detection limit of 1.63 nM. Finally, the flexible heterostructured sensing platform realizes real-time monitoring of O-2(center dot-) in live cell assays, offering a promising flexible biosensor towards exploring various biological processes.
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