Journal
MONATSHEFTE FUR CHEMIE
Volume 151, Issue 10, Pages 1621-1628Publisher
SPRINGER WIEN
DOI: 10.1007/s00706-020-02686-3
Keywords
Antibacterial; Drug discovery; Heterocycles; Quinoline; Synthesis
Categories
Funding
- Mustansiriyah University
- University of Technology
- CAS President's International Fellowship Initiative [2016PM032]
- Chinese Academy of Sciences (CAS)
Ask authors/readers for more resources
A novel series of quinolone-based heterocyclic derivatives including thiadiazine, thiadiazoles, and triazole were synthesized and their in vitro antibacterial activity against Gram-positive and Gram-negative bacteria were evaluated. Newly synthesized derivatives have been obtained in good yields ranging from 65 to 80%. The synthesized derivatives have been characterized and their structures identified using spectroscopic analysis including NMR, FT-IR, and mass techniques. Most of compounds exhibited moderate-to-good antibacterial activity against all four bacterial strains and are significantly more active than ampicillin. Compounds showed relatively good anti-bacterial activity compared to moderate activity of other compounds. The results obtained herein are important for further structure modifications of quinoline bearing heterocyclic moiety and the exploitation of the therapeutic potential of quinoline derivatives as antibacterial agents. Graphic abstract
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available