4.6 Review

Capturing Peptide-GPCR Interactions and Their Dynamics

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Dynamic G Protein-Coupled Receptor Signaling Probed by Solution NMR Spectroscopy

Sho Hee Park et al.

BIOCHEMISTRY (2020)

Article Biochemistry & Molecular Biology

Molecular Basis for Hormone Recognition and Activation of Corticotropin-Releasing Factor Receptors

Shanshan Ma et al.

MOLECULAR CELL (2020)

Article Biochemistry & Molecular Biology

Toward a Structural Understanding of Class B GPCR Peptide Binding and Activation

Yi-Lynn Liang et al.

MOLECULAR CELL (2020)

Article Multidisciplinary Sciences

Structure of the neurotensin receptor 1 in complex with β-arrestin 1

Weijiao Huang et al.

NATURE (2020)

Review Biochemical Research Methods

Expression and purification of recombinant G protein-coupled receptors: A review

Daniel N. Wiseman et al.

PROTEIN EXPRESSION AND PURIFICATION (2020)

Article Multidisciplinary Sciences

Molecular mechanism of biased signaling in a prototypical G protein-coupled receptor

Carl-Mikael Suomivuori et al.

SCIENCE (2020)

Article Biochemistry & Molecular Biology

Biased Signaling of the G-Protein-Coupled Receptor β2AR Is Governed by Conformational Exchange Kinetics

Rajan Lamichhane et al.

STRUCTURE (2020)

Article Multidisciplinary Sciences

Structural basis of Gs and Gi recognition by the human glucagon receptor

Anna Qiao et al.

SCIENCE (2020)

Article Biochemistry & Molecular Biology

A Conserved Proline Hinge Mediates Helix Dynamics and Activation of Rhodopsin

Andreyah L. Pope et al.

STRUCTURE (2020)

Review Biotechnology & Applied Microbiology

Advances in therapeutic peptides targeting G protein-coupled receptors

Anthony P. Davenport et al.

NATURE REVIEWS DRUG DISCOVERY (2020)

Article Chemistry, Multidisciplinary

The Conformational Equilibrium of the Neuropeptide Y2 Receptor in Bilayer Membranes

Ulrike Krug et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Article Biochemistry & Molecular Biology

Developing Covalent Protein Drugs via Proximity-Enabled Reactive Therapeutics

Qingke Li et al.

Article Biochemistry & Molecular Biology

Exploring GPCR-arrestin interfaces with genetically encoded crosslinkers

Thore Boettke et al.

EMBO REPORTS (2020)

Article Multidisciplinary Sciences

Structure and dynamics of the active Gs-coupled human secretin receptor

Maoqing Dong et al.

NATURE COMMUNICATIONS (2020)

Article Multidisciplinary Sciences

Conformational dynamics of a G protein-coupled receptor helix 8 in lipid membranes

Patricia M. Dijkman et al.

SCIENCE ADVANCES (2020)

Review Pharmacology & Pharmacy

Biased Receptor Signaling in Drug Discovery

Terry Kenakin

PHARMACOLOGICAL REVIEWS (2019)

Article Biochemistry & Molecular Biology

Structural Model of Ghrelin Bound to its G Protein-Coupled Receptor

Brian Joseph Bender et al.

STRUCTURE (2019)

Article Biochemistry & Molecular Biology

Quantitative Single-Residue Bioorthogonal Labeling of G Protein-Coupled Receptors in Live Cells

Robert Serfling et al.

ACS CHEMICAL BIOLOGY (2019)

Article Biochemistry & Molecular Biology

Structural Insights into the Process of GPCR-G Protein Complex Formation

Xiangyu Liu et al.

Article Biochemistry & Molecular Biology

Assembly of a GPCR-G Protein Complex

Yang Du et al.

Article Multidisciplinary Sciences

Conformational plasticity of the intracellular cavity of GPCR-G-protein complexes leads to G-protein promiscuity and selectivity

Manbir Sandhu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Review Chemistry, Medicinal

NMR investigation of protein-ligand interactions for G-protein coupled receptors

Claire Raingeval et al.

FUTURE MEDICINAL CHEMISTRY (2019)

Article Multidisciplinary Sciences

Conformational transitions of a neurotensin receptor 1-Gi1 complex

Hideaki E. Kato et al.

NATURE (2019)

Article Cell Biology

Studying GPCR conformational dynamics by single molecule fluorescence

Robert B. Quast et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2019)

Article Multidisciplinary Sciences

Structure and dynamics of G protein-coupled receptor-bound ghrelin reveal the critical role of the octanoyl chain

Guillaume Ferre et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Multidisciplinary Sciences

Elucidating the active δ-opioid receptor crystal structure with peptide and small-molecule agonists

Tobias Claff et al.

SCIENCE ADVANCES (2019)

Article Biochemistry & Molecular Biology

Angiotensin Analogs with Divergent Bias Stabilize Distinct Receptor Conformations

Laura M. Wingler et al.

Article Biochemistry & Molecular Biology

Distinctive Activation Mechanism for Angiotensin Receptor Revealed by a Synthetic Nanobody

Laura M. Wingler et al.

Article Biochemistry & Molecular Biology

Exploring Pairwise Chemical Crosslinking To Study Peptide-Receptor Interactions

Lisa Seidel et al.

CHEMBIOCHEM (2019)

Review Biotechnology & Applied Microbiology

GPCR drug discovery: integrating solution NMR data with crystal and cryo-EM structures

Ichio Shimada et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

Article Multidisciplinary Sciences

Conformational pathway provides unique sensitivity to a synaptic mGluR

Chris H. Habrian et al.

NATURE COMMUNICATIONS (2019)

Article Biology

Common activation mechanism of class A GPCRs

Qingtong Zhou et al.

ELIFE (2019)

Article Chemistry, Medicinal

The Molecular Control of Calcitonin Receptor Signaling

Emma dal Maso et al.

ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE (2019)

Article Multidisciplinary Sciences

Structure and dynamics of the active human parathyroid hormone receptor-1

Li-Hua Zhao et al.

SCIENCE (2019)

Article Engineering, Biomedical

Single-molecule FRET methods to study the dynamics of proteins at work

Hisham Mazal et al.

CURRENT OPINION IN BIOMEDICAL ENGINEERING (2019)

Article Chemistry, Medicinal

The Current State of Peptide Drug Discovery: Back to the Future?

Antoine Henninot et al.

JOURNAL OF MEDICINAL CHEMISTRY (2018)

Article Biochemistry & Molecular Biology

GPCRdb in 2018: adding GPCR structure models and ligands

Gaspar Pandy-Szekeres et al.

NUCLEIC ACIDS RESEARCH (2018)

Article Chemistry, Multidisciplinary

Multiple Binding Sites Contribute to the Mechanism of Mixed Agonistic and Positive Allosteric Modulators of the Cannabinoid CB1 Receptor

Noureldin Saleh et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

Article Biochemistry & Molecular Biology

Allosteric Coupling of Drug Binding and Intracellular Signaling in the A(2A) Adenosine Receptor

Matthew T. Eddy et al.

Review Endocrinology & Metabolism

Current understanding of the structure and function of family B GPCRs to design novel drugs

Vlasios Karageorgos et al.

HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (2018)

Article Biochemistry & Molecular Biology

The arrestin-1 finger loop interacts with two distinct conformations of active rhodopsin

Matthias Elgeti et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

Article Chemistry, Multidisciplinary

Extrinsic Tryptophans as NMR Probes of Allosteric Coupling in Membrane Proteins: Application to the A(2A) Adenosine Receptor

Matthew T. Eddy et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

Article Pharmacology & Pharmacy

G Protein-Coupled Receptors as Targets for Approved Drugs: How Many Targets and How Many Drugs?

Krishna Sriram et al.

MOLECULAR PHARMACOLOGY (2018)

Article Multidisciplinary Sciences

Structural basis of ligand binding modes at the neuropeptide Y Y-1 receptor

Zhenlin Yang et al.

NATURE (2018)

Article Biochemistry & Molecular Biology

The molecular basis of subtype selectivity of human kinin G-protein-coupled receptors

Lisa Joedicke et al.

NATURE CHEMICAL BIOLOGY (2018)

Review Biochemistry & Molecular Biology

Structure and dynamics of GPCR signaling complexes

Daniel Hilger et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)

Article Multidisciplinary Sciences

G(i)- and G(s)-coupled GPCRs show different modes of G-protein binding

Ned Van Eps et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Biochemistry & Molecular Biology

Integrated Structural Biology for alpha-Helical Membrane Protein Structure Determination

Yan Xia et al.

STRUCTURE (2018)

Review Pharmacology & Pharmacy

Intramolecular and Intermolecular FRET Sensors for GPCRs - Monitoring Conformational Changes and Beyond

Michael Kauk et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2018)

Review Pharmacology & Pharmacy

Single-Molecule Imaging of GPCR Interactions

Davide Calebiro et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2018)

Article Multidisciplinary Sciences

Phosphorylation-induced conformation of β2-adrenoceptor related to arrestin recruitment revealed by NMR

Yutaro Shiraishi et al.

NATURE COMMUNICATIONS (2018)

Review Biochemistry & Molecular Biology

Structure and dynamics of GPCR signaling complexes

Daniel Hilger et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)

Article Pharmacology & Pharmacy

Binding, Thermodynamics, and Selectivity of a Non-peptide Antagonist to the Melanocortin-4 Receptor

Noureldin Saleh et al.

FRONTIERS IN PHARMACOLOGY (2018)

Review Chemistry, Multidisciplinary

Expanding the Genetic Code to Study Protein-Protein Interactions

Tuan-Anh Nguyen et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

Review Biochemistry & Molecular Biology

Application of non-canonical crosslinking amino acids to study protein-protein interactions in live cells

Irene Coin

CURRENT OPINION IN CHEMICAL BIOLOGY (2018)

Article Multidisciplinary Sciences

Cryo-EM structure of human rhodopsin bound to an inhibitory G protein

Yanyong Kang et al.

NATURE (2018)

Article Multidisciplinary Sciences

Structure of the glucagon receptor in complex with a glucagon analogue

Haonan Zhang et al.

NATURE (2018)

Article Multidisciplinary Sciences

Cryo-EM structure of the active, G(s)- protein complexed, human CGRP receptor

Yi-Lynn Liang et al.

NATURE (2018)

Article Multidisciplinary Sciences

Structure of the μ-opioid receptor-Gi protein complex

Antoine Koehl et al.

NATURE (2018)

Article Multidisciplinary Sciences

Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex

Yi-Lynn Liang et al.

NATURE (2018)

Article Biochemical Research Methods

Precision and accuracy of single-molecule FRET measurements-a multi-laboratory benchmark study

Bjoern Hellenkamp et al.

NATURE METHODS (2018)

Article Multidisciplinary Sciences

Proximity-enhanced SuFEx chemical cross-linker for specific and multitargeting cross-linking mass spectrometry

Bing Yang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Multidisciplinary Sciences

A(2A) adenosine receptor functional states characterized by F-19-NMR

Lukas Susac et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Review Chemistry, Multidisciplinary

Labeling and Single-Molecule Methods To Monitor G Protein-Coupled Receptor Dynamics

He Tian et al.

CHEMICAL REVIEWS (2017)

Review Biochemistry & Molecular Biology

Chemokines from a Structural Perspective

Michelle C. Miller et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Review Biochemistry & Molecular Biology

Structure and Function of Peptide-Binding G Protein-Coupled Receptors

Fan Wu et al.

JOURNAL OF MOLECULAR BIOLOGY (2017)

Review Biochemical Research Methods

Protein Footprinting Comes of Age: Mass Spectrometry for Biophysical Structure Assessment

Liwen Wang et al.

MOLECULAR & CELLULAR PROTEOMICS (2017)

Article Multidisciplinary Sciences

Phase-plate cryo-EM structure of a class B GPCR-G-protein complex

Yi-Lynn Liang et al.

NATURE (2017)

Article Multidisciplinary Sciences

Selectivity determinants of GPCR-G-protein binding

Tilman Flock et al.

NATURE (2017)

Article Multidisciplinary Sciences

Single-molecule analysis of ligand efficacy in β2AR-G-protein activation

G. Glenn Gregorio et al.

NATURE (2017)

Article Multidisciplinary Sciences

Crystal structure of the GLP-1 receptor bound to a peptide agonist

Ali Jazayeri et al.

NATURE (2017)

Article Multidisciplinary Sciences

Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein

Yan Zhang et al.

NATURE (2017)

Article Biotechnology & Applied Microbiology

Trends in GPCR drug discovery: new agents, targets and indications

Alexander S. Hauser et al.

NATURE REVIEWS DRUG DISCOVERY (2017)

Article Biochemical Research Methods

Genetically encoding new bioreactivity

Lei Wang

NEW BIOTECHNOLOGY (2017)

Article Multidisciplinary Sciences

Conformational equilibria of light-activated rhodopsin in nanodiscs

Ned Van Eps et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Review Chemistry, Physical

Dynamic nuclear polarization for sensitivity enhancement in modern solid-state NMR

Aany Sofia Lilly Thankamony et al.

PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY (2017)

Article Biochemistry & Molecular Biology

Structural Basis for Apelin Control of the Human Apelin Receptor

Yingli Ma et al.

STRUCTURE (2017)

Article Chemistry, Medicinal

Photoaffinity Labeling of the Human A2A Adenosine Receptor and Cross-link Position Analysis by Mass Spectrometry

Hideyuki Muranaka et al.

ACS MEDICINAL CHEMISTRY LETTERS (2017)

Article Multidisciplinary Sciences

C-edge loops of arrestin function as a membrane anchor

Ciara C. M. Lally et al.

NATURE COMMUNICATIONS (2017)

Article Chemistry, Multidisciplinary

Differences between G-Protein-Stabilized Agonist-GPCR Complexes and their Nanobody-Stabilized Equivalents

Noureldin Saleh et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

Article Chemistry, Multidisciplinary

Proximity-Triggered Covalent Stabilization of Low-Affinity Protein Complexes In Vitro and In Vivo

Marko Cigler et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

Article Biochemistry & Molecular Biology

Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors

X. Edward Zhou et al.

Article Chemistry, Multidisciplinary

Identification of Two Distinct Sites for Antagonist and Biased Agonist Binding to the Human Chemokine Receptor CXCR3

Lampros Milanos et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)

Article Chemistry, Multidisciplinary

A Three-Site Mechanism for Agonist/Antagonist Selective Binding to Vasopressin Receptors

Noureldin Saleh et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)

Article Biochemistry & Molecular Biology

The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism

Denise Wootten et al.

Article Chemistry, Multidisciplinary

Functional Modulation of a G Protein-Coupled Receptor Conformational Landscape in a Lipid Bilayer

Marina Casiraghi et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2016)

Review Biochemistry & Molecular Biology

Peptide-tags for site-specific protein labelling in vitro and in vivo

Jonathan Lotze et al.

MOLECULAR BIOSYSTEMS (2016)

Article Multidisciplinary Sciences

Allosteric coupling from G protein to the agonist-binding pocket in GPCRs

Brian T. DeVree et al.

NATURE (2016)

Article Multidisciplinary Sciences

Activation mechanism of endothelin ETB receptor by endothelin-1

Wataru Shihoya et al.

NATURE (2016)

Article Multidisciplinary Sciences

Diverse activation pathways in class A GPCRs converge near the G-protein-coupling region

A. J. Venkatakrishnan et al.

NATURE (2016)

Article Biochemistry & Molecular Biology

Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor

Alem W. Kahsai et al.

NATURE CHEMICAL BIOLOGY (2016)

Article Multidisciplinary Sciences

Signal transmission through the CXC chemokine receptor 4 (CXCR4) transmembrane helices

Melanie P. Wescott et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Biochemistry & Molecular Biology

β2-Adrenergic Receptor Conformational Response to Fusion Protein in the Third Intracellular Loop

Matthew T. Eddy et al.

STRUCTURE (2016)

Review Pharmacology & Pharmacy

Successful Strategies to Determine High-Resolution Structures of GPCRs

Jin Xiang et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2016)

Article Biochemistry & Molecular Biology

EPR Distance Measurements in Native Proteins with Genetically Encoded Spin Labels

Moritz J. Schmidt et al.

ACS CHEMICAL BIOLOGY (2015)

Article Chemistry, Multidisciplinary

Unwinding of the C-Terminal Residues of Neuropeptide Y is critical for Y2 Receptor Binding and Activation

Anette Kaiser et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)

Article Chemistry, Multidisciplinary

Identification of a Conformational Equilibrium That Determines the Efficacy and Functional Selectivity of the μ-Opioid Receptor

Junya Okude et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)

Article Biochemistry & Molecular Biology

Structural Insights into the Dynamic Process of β2-Adrenergic Receptor Signaling

Aashish Manglik et al.

Article Multidisciplinary Sciences

Conformational dynamics of a class C G-protein-coupled receptor

Reza Vafabakhsh et al.

NATURE (2015)

Article Multidisciplinary Sciences

Propagation of conformational changes during μ-opioid receptor activation

Remy Sounier et al.

NATURE (2015)

Article Multidisciplinary Sciences

Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser

Yanyong Kang et al.

NATURE (2015)

Review Biochemistry & Molecular Biology

Characterizing rhodopsin signaling by EPR spectroscopy: from structure to dynamics

Ned Van Eps et al.

PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES (2015)

Article Multidisciplinary Sciences

Single-molecule view of basal activity and activation mechanisms of the G protein-coupled receptor β2AR

Rajan Lamichhane et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Multidisciplinary Sciences

NMR structure and dynamics of the agonist dynorphin peptide bound to the human kappa opioid receptor

Casey O'Connor et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Biochemistry & Molecular Biology

Major ligand-induced rearrangement of the heptahelical domain interface in a GPCR dimer

Li Xue et al.

NATURE CHEMICAL BIOLOGY (2015)

Article Chemistry, Multidisciplinary

Characterization of the Simultaneous Decay Kinetics of Metarhodopsin States II and III in Rhodopsin by Solution-State NMR Spectroscopy

Jochen Stehle et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)

Article Chemistry, Multidisciplinary

Proximity-Enabled Protein Crosslinking through Genetically Encoding Haloalkane Unnatural Amino Acids

Zheng Xiang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)

Article Chemistry, Multidisciplinary

Functional Dynamics of Deuterated β2-Adrenergic Receptor in Lipid Bilayers Revealed by NMR Spectroscopy

Yutaka Kofuku et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)

Review Chemistry, Multidisciplinary

Cellular Incorporation of Unnatural Amino Acids and Bioorthogonal Labeling of Proteins

Kathrin Lang et al.

CHEMICAL REVIEWS (2014)

Review Biochemistry & Molecular Biology

Chemical Biology Methods for Investigating G Protein-Coupled Receptor Signaling

Thomas Huber et al.

CHEMISTRY & BIOLOGY (2014)

Article Cell Biology

The role of protein dynamics in GPCR function: insights from the β2AR and rhodopsin

Aashish Manglik et al.

CURRENT OPINION IN CELL BIOLOGY (2014)

Article Cell Biology

Kinetics and mechanism of G protein-coupled receptor activation

Martin J. Lohse et al.

CURRENT OPINION IN CELL BIOLOGY (2014)

Review Biochemistry & Molecular Biology

New chemistries for chemoselective peptide ligations and the total synthesis of proteins

Thibault J. R. Harmand et al.

CURRENT OPINION IN CHEMICAL BIOLOGY (2014)

Article Biochemistry & Molecular Biology

Structured and disordered facets of the GPCR fold

A. J. Venkatakrishnan et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2014)

Article Biochemistry & Molecular Biology

Identification of Receptor Binding-induced Conformational Changes in Non-visual Arrestins

Ya Zhuo et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Biochemistry & Molecular Biology

Mapping Substance P Binding Sites on the Neurokinin-1 Receptor Using Genetic Incorporation of a Photoreactive Amino Acid

Louise Valentin-Hansen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Chemistry, Multidisciplinary

A Genetically Encoded Spin Label for Electron Paramagnetic Resonance Distance Measurements

Moritz J. Schmidt et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)

Article Multidisciplinary Sciences

Visualization of arrestin recruitment by a G-protein-coupled receptor

Arun K. Shukla et al.

NATURE (2014)

Article Multidisciplinary Sciences

Structure of signaling-competent neurotensin receptor 1 obtained by directed evolution in Escherichia coli

Pascal Egloff et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Multidisciplinary Sciences

Stoichiometry and geometry of the CXC chemokine receptor 4 complex with CXC ligand 12: Molecular modeling and experimental validation

Irina Kufareva et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Review Pharmacology & Pharmacy

Insights into the structure of class B GPCRs

Kaspar Hollenstein et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2014)

Article Multidisciplinary Sciences

Fine tuning of sub-millisecond conformational dynamics controls metabotropic glutamate receptors agonist efficacy

Linnea Olofsson et al.

NATURE COMMUNICATIONS (2014)

Article Chemistry, Multidisciplinary

β2-Adrenergic Receptor Activation by Agonists Studied with 19F NMR Spectroscopy

Reto Horst et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2013)

Review Pharmacology & Pharmacy

Structure-Function of the G Protein-Coupled Receptor Superfamily

Vsevolod Katritch et al.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 53, 2013 (2013)

Review Biochemistry & Molecular Biology

Site-directed spin labeling EPR spectroscopy in protein research

Johann P. Klare

BIOLOGICAL CHEMISTRY (2013)

Editorial Material Biochemistry & Molecular Biology

Structure Modeling Using Genetically Engineered Crosslinking

Kuntal Pal et al.

Article Biochemistry & Molecular Biology

The Dynamic Process of β2-Adrenergic Receptor Activation

Rie Nygaard et al.

Article Biochemistry & Molecular Biology

Fluorine-19 NMR of integral membrane proteins illustrated with studies of GPCRs

Tatiana Didenko et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2013)

Article Biochemistry & Molecular Biology

Biophysical and structural investigation of bacterially expressed and engineered CCR5, a G protein-coupled receptor

Maciej Wiktor et al.

JOURNAL OF BIOMOLECULAR NMR (2013)

Article Chemistry, Multidisciplinary

The Role of Ligands on the Equilibria Between Functional States of a G Protein-Coupled Receptor

Tae Hun Kim et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)

Article Chemistry, Multidisciplinary

Precision vs Flexibility in GPCR signaling

Matthias Elgeti et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)

Article Multidisciplinary Sciences

Structure of class B GPCR corticotropin-releasing factor receptor 1

Kaspar Hollenstein et al.

NATURE (2013)

Review Multidisciplinary Sciences

Molecular signatures of G-protein-coupled receptors

A. J. Venkatakrishnan et al.

NATURE (2013)

Article Biochemical Research Methods

Adding an unnatural covalent bond to proteins through proximity-enhanced bioreactivity

Zheng Xiang et al.

NATURE METHODS (2013)

Article Biochemistry & Molecular Biology

Conformation propensities of des-acyl-ghrelin as probed by CD and NMR

Riccardo De Ricco et al.

PEPTIDES (2013)

Article Multidisciplinary Sciences

Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations

Denise Wootten et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Editorial Material Multidisciplinary Sciences

Integrative Structural Biology

Andrew B. Ward et al.

SCIENCE (2013)

Article Biochemistry & Molecular Biology

Genetically Encoded Photo-cross-linkers Map the Binding Site of an Allosteric Drug on a G Protein-Coupled Receptor

Amy Grunbeck et al.

ACS CHEMICAL BIOLOGY (2012)

Review Chemistry, Multidisciplinary

Structure and mechanism for recognition of peptide hormones by Class B G-protein-coupled receptors

Kuntal Pal et al.

ACTA PHARMACOLOGICA SINICA (2012)

Article Biochemistry & Molecular Biology

Rhodopsin Forms a Dimer with Cytoplasmic Helix 8 Contacts in Native Membranes

Adam M. Knepp et al.

BIOCHEMISTRY (2012)

Article Biochemistry & Molecular Biology

Ligand-mimicking Receptor Variant Discloses Binding and Activation Mode of Prolactin-releasing Peptide

Daniel Rathmann et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Biochemistry & Molecular Biology

Role of Detergents in Conformational Exchange of a G Protein-coupled Receptor

Ka Young Chung et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Biochemistry & Molecular Biology

Lysine methylation strategies for characterizing protein conformations by NMR

Sacha Thierry Larda et al.

JOURNAL OF BIOMOLECULAR NMR (2012)

Article Multidisciplinary Sciences

Structure of the agonist-bound neurotensin receptor

Jim F. White et al.

NATURE (2012)

Article Multidisciplinary Sciences

Ligands and signaling proteins govern the conformational landscape explored by a G protein-coupled receptor

Sophie Mary et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Multidisciplinary Sciences

α-Helical element at the hormone-binding surface of the insulin receptor functions as a signaling element to activate its tyrosine kinase

Jonathan Whittaker et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Multidisciplinary Sciences

Structural insights into biased G protein-coupled receptor signaling revealed by fluorescence spectroscopy

Rita Rahmeh et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Editorial Material Multidisciplinary Sciences

Versatility from Protein Disorder

M. Madan Babu et al.

SCIENCE (2012)

Article Multidisciplinary Sciences

Biased Signaling Pathways in β2-Adrenergic Receptor Characterized by 19F-NMR

Jeffrey J. Liu et al.

SCIENCE (2012)

Review Pharmacology & Pharmacy

Domain coupling in GPCRs: the engine for induced conformational changes

Hamiyet Unal et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2012)

Article Multidisciplinary Sciences

The allosteric vestibule of a seven transmembrane helical receptor controls G-protein coupling

Andreas Bock et al.

NATURE COMMUNICATIONS (2012)

Article Chemistry, Multidisciplinary

Photo-Cross-Linkers Incorporated into G-Protein-Coupled Receptors in Mammalian Cells: A Ligand Comparison

Irene Coin et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)

Article Biochemistry & Molecular Biology

Local and Global Dynamics of the G Protein-Coupled Receptor CXCR1

Sang Ho Park et al.

BIOCHEMISTRY (2011)

Article Biochemistry & Molecular Biology

Structure Analysis of an Amyloid-Forming Model Peptide by a Systematic Glycine and Proline Scan

Ulla I. M. Gerling et al.

BIOMACROMOLECULES (2011)

Article Biochemistry & Molecular Biology

Structural insights into agonist-induced activation of G-protein-coupled receptors

Xavier Deupi et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2011)

Article Chemistry, Physical

Conformational Dynamics of Single G Protein-Coupled Receptors in Solution

Samuel Bockenhauer et al.

JOURNAL OF PHYSICAL CHEMISTRY B (2011)

Article Biochemistry & Molecular Biology

Multiple ligand-specific conformations of the β2-adrenergic receptor

Alem W. Kahsai et al.

NATURE CHEMICAL BIOLOGY (2011)

Article Biochemical Research Methods

A rapid and robust method for selective isotope labeling of proteins

Myat T. Lin et al.

METHODS (2011)

Article Multidisciplinary Sciences

Interaction of a G protein with an activated receptor opens the interdomain interface in the alpha subunit

Ned Van Eps et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Multidisciplinary Sciences

Pathway and mechanism of drug binding to G-protein-coupled receptors

Ron O. Dror et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Review Biotechnology & Applied Microbiology

New advances in production and functional folding of G-protein-coupled receptors

Jean-Louis Baneres et al.

TRENDS IN BIOTECHNOLOGY (2011)

Review Biochemistry & Molecular Biology

Adding New Chemistries to the Genetic Code

Chang C. Liu et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 79 (2010)

Article Biochemistry & Molecular Biology

Cell-free expression and stable isotope labelling strategies for membrane proteins

Solmaz Sobhanifar et al.

JOURNAL OF BIOMOLECULAR NMR (2010)

Article Biochemistry & Molecular Biology

Methyl groups as probes of supra-molecular structure, dynamics and function

Amy M. Ruschak et al.

JOURNAL OF BIOMOLECULAR NMR (2010)

Article Chemistry, Multidisciplinary

Sequential Rearrangement of Interhelical Networks Upon Rhodopsin Activation in Membranes: The Meta IIa Conformational Substate

Ekaterina Zaitseva et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)

Article Chemistry, Multidisciplinary

NMR Analyses of the Interaction between CCR5 and Its Ligand Using Functional Reconstitution of CCR5 in Lipid Bilayers

Chie Yoshiura et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)

Article Multidisciplinary Sciences

Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor

Michael P. Bokoch et al.

NATURE (2010)

Article Biochemistry & Molecular Biology

The role of conformational entropy in molecular recognition by calmodulin

Michael S. Marlow et al.

NATURE CHEMICAL BIOLOGY (2010)

Review Biotechnology & Applied Microbiology

Teaching old receptors new tricks: biasing seven-transmembrane receptors

Sudarshan Rajagopal et al.

NATURE REVIEWS DRUG DISCOVERY (2010)

Article Multidisciplinary Sciences

Highly conserved tyrosine stabilizes the active state of rhodopsin

Joseph A. Goncalves et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Review Chemistry, Multidisciplinary

Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality

Ellen M. Sletten et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2009)

Article Biochemistry & Molecular Biology

Cross-Linking of a DOPA-Containing Peptide Ligand into Its G Protein-Coupled Receptor

George K. E. Umanah et al.

BIOCHEMISTRY (2009)

Article Biochemistry & Molecular Biology

Lipid Protein Interactions Couple Protonation to Conformation in a Conserved Cytosolic Domain of G Protein-coupled Receptors

Sineej Madathil et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Biochemistry & Molecular Biology

Structural Basis of the Interaction between Chemokine Stromal Cell-derived Factor-1/CXCL12 and Its G-protein-coupled Receptor CXCR4

Yutaka Kofuku et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Biochemistry & Molecular Biology

TALOS plus : a hybrid method for predicting protein backbone torsion angles from NMR chemical shifts

Yang Shen et al.

JOURNAL OF BIOMOLECULAR NMR (2009)

Article Biochemistry & Molecular Biology

FTIR analysis of GPCR activation using azido probes

Shixin Ye et al.

NATURE CHEMICAL BIOLOGY (2009)

Article Biochemistry & Molecular Biology

Helix movement is coupled to displacement of the second extracellular loop in rhodopsin activation

Shivani Ahuja et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2009)

Review Plant Sciences

Spin labeling EPR

Johann P. Klare et al.

PHOTOSYNTHESIS RESEARCH (2009)

Article Multidisciplinary Sciences

Site-directed spin labeling of a genetically encoded unnatural amino acid

Mark R. Fleissner et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Review Chemistry, Physical

Recent advances in the application of solution NMR spectroscopy to multi-span integral membrane proteins

Hak Jun Kim et al.

PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY (2009)

Review Biochemistry & Molecular Biology

Observing biological dynamics at atomic resolution using NMR

Anthony K. Mittermaier et al.

TRENDS IN BIOCHEMICAL SCIENCES (2009)

Article Biochemistry & Molecular Biology

Mapping peptide hormone-receptor interactions using a disulfide-trapping approach

Paul Monaghan et al.

BIOCHEMISTRY (2008)

Article Biochemistry & Molecular Biology

Structure of the complement factor 5a receptor-ligand complex studied by disulfide trapping and molecular modeling

Ian S. Hagemann et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Review Biochemistry & Molecular Biology

Photocrosslinkers illuminate interactions in living cells

Yoshihito Tanaka et al.

MOLECULAR BIOSYSTEMS (2008)

Article Multidisciplinary Sciences

Two protonation switches control rhodopsin activation in membranes

Mohana Mahalingam et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Multidisciplinary Sciences

High-resolution distance mapping in rhodopsin reveals the pattern of helix movement due to activation

Christian Altenbach et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Multidisciplinary Sciences

Energy transformations early in the bacteriorhodopsin photocycle revealed by DNP-enhanced solid-state NMR

Melody L. Mak-Jurkauskas et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Review Pharmacology & Pharmacy

New G-protein-coupled receptor crystal structures: insights and limitations

Brian Kobilka et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2008)

Article Multidisciplinary Sciences

Sequence of late molecular events in the activation of rhodopsin

Bernhard Knierim et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Multidisciplinary Sciences

Conformational entropy in molecular recognition by proteins

Kendra King Frederick et al.

NATURE (2007)

Article Biochemistry & Molecular Biology

Structure and function of the visual arrestin oligomer

Susan M. Hanson et al.

EMBO JOURNAL (2007)

Article Biochemistry & Molecular Biology

Receptor subtype-specific docking of Asp6.59 with C-terminal arginine residues in Y receptor ligands

Nicole Merten et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Review Biochemistry & Molecular Biology

Infrared spectroscopy of proteins

Andreas Barth

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2007)

Article Multidisciplinary Sciences

Structural and dynamical changes in an α-subunit of a heterotrimeric G protein along the activation pathway

Ned Van Eps et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Biochemistry & Molecular Biology

Multi-template approach to modeling engineered disulfide bonds

Jean-Luc Pellequer et al.

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2006)

Article Biochemistry & Molecular Biology

Probing the activation-promoted structural rearrangements in preassembled receptor-G protein complexes

Celine Gales et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2006)

Article Biochemistry & Molecular Biology

Coupling ligand structure to specific conformational switches in the β2-adrenoceptor

Xiaojie Yao et al.

NATURE CHEMICAL BIOLOGY (2006)

Article Biochemistry & Molecular Biology

Location of Trp265 in metarhodopsin II: Implications for the activation mechanism of the visual receptor rhodopsin

E Crocker et al.

JOURNAL OF MOLECULAR BIOLOGY (2006)

Article Biochemistry & Molecular Biology

The mid-region of parathyroid hormone (1-34) serves as a functional docking domain in receptor activation

A Wittelsberger et al.

BIOCHEMISTRY (2006)

Article Multidisciplinary Sciences

Turn-on switch in parathyroid hormone receptor by a two-step parathyroid hormone binding mechanism

M Castro et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemistry & Molecular Biology

The role of Glu181 in the photoactivation of rhodopsin

S Lüdeke et al.

JOURNAL OF MOLECULAR BIOLOGY (2005)

Article Biochemistry & Molecular Biology

Agonists and partial agonists of rhodopsin:: Retinals with ring modifications

R Vogel et al.

BIOCHEMISTRY (2005)

Article Multidisciplinary Sciences

Disulfide trapping to localize small-molecule agonists and antagonists for a G protein-coupled receptor

E Buck et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Review Biochemistry & Molecular Biology

Photoaffinity scanning in the mapping of the peptide receptor interface of class II G protein-coupled receptors

VI Pham et al.

JOURNAL OF PEPTIDE SCIENCE (2004)

Article Biochemistry & Molecular Biology

Sequential binding of agonists to the β2 adrenoceptor -: Kinetic evidence for intermediate conformational states

G Swaminath et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Chemistry, Multidisciplinary

High-frequency dynamic nuclear polarization in MAS spectra of membrane and soluble proteins

M Rosay et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2003)

Article Multidisciplinary Sciences

The conformation of neurotensin bound to its G protein-coupled receptor

S Luca et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Chemistry, Multidisciplinary

Cross-correlated relaxation enhanced 1H-13C NMR spectroscopy of methyl groups in very high molecular weight proteins and protein complexes

V Tugarinov et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2003)

Review Chemistry, Multidisciplinary

NMR Spectroscopy techniques for screening and identifying ligand binding to protein receptors

B Meyer et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2003)

Article Multidisciplinary Sciences

Single-molecule spectroscopy of the β2 adrenergic receptor:: Observation of conformational substates in a membrane protein

G Peleg et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

Article Biochemistry & Molecular Biology

Functionally different agonists induce distinct conformations in the G protein coupling domain of the β2 adrenergic receptor

P Ghanouni et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

Article Multidisciplinary Sciences

Agonist-induced conformational changes in the G-protein-coupling domain of the β2 adrenergic receptor

P Ghanouni et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

Article Multidisciplinary Sciences

Solution 19F nuclear Overhauser effects in structural studies of the cytoplasmic domain of mammalian rhodopsin

MC Loewen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

Article Biochemistry & Molecular Biology

Conformation of a peptide ligand bound to its G-protein coupled receptor

H Inooka et al.

NATURE STRUCTURAL BIOLOGY (2001)

Review Biochemistry & Molecular Biology

The renaissance of fluorescence resonance energy transfer

PR Selvin

NATURE STRUCTURAL BIOLOGY (2000)

Review Biochemistry & Molecular Biology

Identifying conformational changes with site-directed spin labeling

WL Hubbell et al.

NATURE STRUCTURAL BIOLOGY (2000)