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Conformational Dynamics of Activation for the Pentameric Complex of Dimeric G Protein-Coupled Receptor and Heterotrimeric G Protein
Tivadar Orban et al.
STRUCTURE (2012)
Domain coupling in GPCRs: the engine for induced conformational changes
Hamiyet Unal et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2012)
The allosteric vestibule of a seven transmembrane helical receptor controls G-protein coupling
Andreas Bock et al.
NATURE COMMUNICATIONS (2012)
Efficacy of the β2-adrenergic receptor is determined by conformational equilibrium in the transmembrane region
Yutaka Kofuku et al.
NATURE COMMUNICATIONS (2012)
Fluorescence/Bioluminescence Resonance Energy Transfer Techniques to Study G-Protein-Coupled Receptor Activation and Signaling
Martin J. Lohse et al.
PHARMACOLOGICAL REVIEWS (2012)
Photo-Cross-Linkers Incorporated into G-Protein-Coupled Receptors in Mammalian Cells: A Ligand Comparison
Irene Coin et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)
Local and Global Dynamics of the G Protein-Coupled Receptor CXCR1
Sang Ho Park et al.
BIOCHEMISTRY (2011)
Mapping the Ligand-Binding Site on a G Protein-Coupled Receptor (GPCR) Using Genetically Encoded Photocrosslinkers
Amy Grunbeck et al.
BIOCHEMISTRY (2011)
Structure Analysis of an Amyloid-Forming Model Peptide by a Systematic Glycine and Proline Scan
Ulla I. M. Gerling et al.
BIOMACROMOLECULES (2011)
Structural insights into agonist-induced activation of G-protein-coupled receptors
Xavier Deupi et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2011)
Molecular Basis of Secretin Docking to Its Intact Receptor Using Multiple Photolabile Probes Distributed throughout the Pharmacophore
Maoqing Dong et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Conformational Dynamics of Single G Protein-Coupled Receptors in Solution
Samuel Bockenhauer et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2011)
Multiple ligand-specific conformations of the β2-adrenergic receptor
Alem W. Kahsai et al.
NATURE CHEMICAL BIOLOGY (2011)
A rapid and robust method for selective isotope labeling of proteins
Myat T. Lin et al.
METHODS (2011)
Interaction of a G protein with an activated receptor opens the interdomain interface in the alpha subunit
Ned Van Eps et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Pathway and mechanism of drug binding to G-protein-coupled receptors
Ron O. Dror et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Ligand-Dependent Perturbation of the Conformational Ensemble for the GPCR β2 Adrenergic Receptor Revealed by HDX
Graham M. West et al.
STRUCTURE (2011)
Toward the Fourth Dimension of Membrane Protein Structure: Insight into Dynamics from Spin-Labeling EPR Spectroscopy
Hassane S. Mchaourab et al.
STRUCTURE (2011)
New advances in production and functional folding of G-protein-coupled receptors
Jean-Louis Baneres et al.
TRENDS IN BIOTECHNOLOGY (2011)
Dynamics of the β2-Adrenergic G-Protein Coupled Receptor Revealed by Hydrogen-Deuterium Exchange
Xi Zhang et al.
ANALYTICAL CHEMISTRY (2010)
Adding New Chemistries to the Genetic Code
Chang C. Liu et al.
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 79 (2010)
Electron Paramagnetic Resonance Studies of Functionally Active, Nitroxide Spin-Labeled Peptide Analogues of the C-Terminus of a G-Protein α Subunit
Ned Van Eps et al.
BIOCHEMISTRY (2010)
Identification of Residue-to-residue Contact between a Peptide Ligand and Its G Protein-coupled Receptor Using Periodate-mediated Dihydroxyphenylalanine Cross-linking and Mass Spectrometry
George K. E. Umanah et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Cell-free expression and stable isotope labelling strategies for membrane proteins
Solmaz Sobhanifar et al.
JOURNAL OF BIOMOLECULAR NMR (2010)
Methyl groups as probes of supra-molecular structure, dynamics and function
Amy M. Ruschak et al.
JOURNAL OF BIOMOLECULAR NMR (2010)
Sequential Rearrangement of Interhelical Networks Upon Rhodopsin Activation in Membranes: The Meta IIa Conformational Substate
Ekaterina Zaitseva et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)
NMR Analyses of the Interaction between CCR5 and Its Ligand Using Functional Reconstitution of CCR5 in Lipid Bilayers
Chie Yoshiura et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)
Tracking G-protein-coupled receptor activation using genetically encoded infrared probes
Shixin Ye et al.
NATURE (2010)
Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor
Michael P. Bokoch et al.
NATURE (2010)
The role of conformational entropy in molecular recognition by calmodulin
Michael S. Marlow et al.
NATURE CHEMICAL BIOLOGY (2010)
Teaching old receptors new tricks: biasing seven-transmembrane receptors
Sudarshan Rajagopal et al.
NATURE REVIEWS DRUG DISCOVERY (2010)
Highly conserved tyrosine stabilizes the active state of rhodopsin
Joseph A. Goncalves et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality
Ellen M. Sletten et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2009)
Identification of Specific Transmembrane Residues and Ligand-Induced Interface Changes Involved In Homo-Dimer Formation of a Yeast G Protein-Coupled Receptor
Heejung Kim et al.
BIOCHEMISTRY (2009)
Cross-Linking of a DOPA-Containing Peptide Ligand into Its G Protein-Coupled Receptor
George K. E. Umanah et al.
BIOCHEMISTRY (2009)
Lipid Protein Interactions Couple Protonation to Conformation in a Conserved Cytosolic Domain of G Protein-coupled Receptors
Sineej Madathil et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Structural Basis of the Interaction between Chemokine Stromal Cell-derived Factor-1/CXCL12 and Its G-protein-coupled Receptor CXCR4
Yutaka Kofuku et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
TALOS plus : a hybrid method for predicting protein backbone torsion angles from NMR chemical shifts
Yang Shen et al.
JOURNAL OF BIOMOLECULAR NMR (2009)
FTIR analysis of GPCR activation using azido probes
Shixin Ye et al.
NATURE CHEMICAL BIOLOGY (2009)
Helix movement is coupled to displacement of the second extracellular loop in rhodopsin activation
Shivani Ahuja et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2009)
Site-directed spin labeling of a genetically encoded unnatural amino acid
Mark R. Fleissner et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Recent advances in the application of solution NMR spectroscopy to multi-span integral membrane proteins
Hak Jun Kim et al.
PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY (2009)
Observing biological dynamics at atomic resolution using NMR
Anthony K. Mittermaier et al.
TRENDS IN BIOCHEMICAL SCIENCES (2009)
The structure of the neuropeptide bradykinin bound to the human G-protein coupled receptor bradykinin B2 as determined by solid-state NMR spectroscopy
Jakob J. Lopez et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2008)
Mapping peptide hormone-receptor interactions using a disulfide-trapping approach
Paul Monaghan et al.
BIOCHEMISTRY (2008)
Bioluminescence resonance energy transfer assays reveal ligand-specific conformational changes within preformed signaling complexes containing δ-opioid receptors and heterotrimeric G proteins
Nicolas Audet et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Structure of the complement factor 5a receptor-ligand complex studied by disulfide trapping and molecular modeling
Ian S. Hagemann et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Photocrosslinkers illuminate interactions in living cells
Yoshihito Tanaka et al.
MOLECULAR BIOSYSTEMS (2008)
Two protonation switches control rhodopsin activation in membranes
Mohana Mahalingam et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
High-resolution distance mapping in rhodopsin reveals the pattern of helix movement due to activation
Christian Altenbach et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Energy transformations early in the bacteriorhodopsin photocycle revealed by DNP-enhanced solid-state NMR
Melody L. Mak-Jurkauskas et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
New G-protein-coupled receptor crystal structures: insights and limitations
Brian Kobilka et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2008)
Isotope labeling of mammalian GPCRs in HEK293 cells and characterization of the C-terminus of bovine rhodopsin by high resolution liquid NMR spectroscopy
Karla Werner et al.
JOURNAL OF BIOMOLECULAR NMR (2008)
Sequence of late molecular events in the activation of rhodopsin
Bernhard Knierim et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Conformational entropy in molecular recognition by proteins
Kendra King Frederick et al.
NATURE (2007)
Structure and conformational changes in the C-terminal domain of the β2-adrenoceptor -: Insights from fluorescence resonance energy transfer studies
Sebastien Granier et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Structure and function of the visual arrestin oligomer
Susan M. Hanson et al.
EMBO JOURNAL (2007)
Receptor subtype-specific docking of Asp6.59 with C-terminal arginine residues in Y receptor ligands
Nicole Merten et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Infrared spectroscopy of proteins
Andreas Barth
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2007)
Structural and dynamical changes in an α-subunit of a heterotrimeric G protein along the activation pathway
Ned Van Eps et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Multi-template approach to modeling engineered disulfide bonds
Jean-Luc Pellequer et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2006)
Probing the activation-promoted structural rearrangements in preassembled receptor-G protein complexes
Celine Gales et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2006)
Coupling ligand structure to specific conformational switches in the β2-adrenoceptor
Xiaojie Yao et al.
NATURE CHEMICAL BIOLOGY (2006)
Structure and dynamics of dark-state bovine rhodopsin revealed by chemical cross-linking and high-resolution mass spectrometry
Richard B. Jacobsen et al.
PROTEIN SCIENCE (2006)
Location of Trp265 in metarhodopsin II: Implications for the activation mechanism of the visual receptor rhodopsin
E Crocker et al.
JOURNAL OF MOLECULAR BIOLOGY (2006)
The mid-region of parathyroid hormone (1-34) serves as a functional docking domain in receptor activation
A Wittelsberger et al.
BIOCHEMISTRY (2006)
Use of an in situ disulfide cross-linking strategy to study the dynamic properties of the cytoplasmic end of transmembrane domain VI of the M3 muscarinic acetylcholine receptor
SDC Ward et al.
BIOCHEMISTRY (2006)
Turn-on switch in parathyroid hormone receptor by a two-step parathyroid hormone binding mechanism
M Castro et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
The role of Glu181 in the photoactivation of rhodopsin
S Lüdeke et al.
JOURNAL OF MOLECULAR BIOLOGY (2005)
Agonists and partial agonists of rhodopsin:: Retinals with ring modifications
R Vogel et al.
BIOCHEMISTRY (2005)
Small vertical movement of a K+ channel voltage sensor measured with luminescence energy transfer
DJ Posson et al.
NATURE (2005)
Probing the β2 adrenoceptor binding site with catechol reveals differences in binding and activation by agonists and partial agonists
G Swaminath et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Disulfide trapping to localize small-molecule agonists and antagonists for a G protein-coupled receptor
E Buck et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Are hormones from the neuropeptide Y family recognized by their receptors from the membrane-bound state?
R Bader et al.
CHEMBIOCHEM (2005)
Photoaffinity scanning in the mapping of the peptide receptor interface of class II G protein-coupled receptors
VI Pham et al.
JOURNAL OF PEPTIDE SCIENCE (2004)
NMR spectroscopy of phosphorylated wild-type rhodopsin: Mobility of the phosphorylated C-terminus of rhodopsin in the dark and upon light activation
E Getmanova et al.
BIOCHEMISTRY (2004)
Sequential binding of agonists to the β2 adrenoceptor -: Kinetic evidence for intermediate conformational states
G Swaminath et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
High-frequency dynamic nuclear polarization in MAS spectra of membrane and soluble proteins
M Rosay et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2003)
The conformation of neurotensin bound to its G protein-coupled receptor
S Luca et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Cross-correlated relaxation enhanced 1H-13C NMR spectroscopy of methyl groups in very high molecular weight proteins and protein complexes
V Tugarinov et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2003)
The G-protein-coupled receptors in the human genome form five main families.: Phylogenetic analysis, paralogon groups, and fingerprints
R Fredriksson et al.
MOLECULAR PHARMACOLOGY (2003)
Elucidation of the nature of the conformational changes of the EF-interhelical loop in bacteriorhodopsin and of the helix VIII on the cytoplasmic surface of bovine rhodopsin:: A time-resolved fluorescence depolarization study
U Alexiev et al.
JOURNAL OF MOLECULAR BIOLOGY (2003)
NMR Spectroscopy techniques for screening and identifying ligand binding to protein receptors
B Meyer et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2003)
Light-induced changes in the structure and accessibility of the cytoplasmic loops of rhodopsin in the activated MII state
T Mielke et al.
BIOCHEMISTRY (2002)
Use of an in situ disulfide cross-linking strategy to map proximities between amino acid residues in transmembrane domains I and VII of the M3 muscarinic acetylcholine receptor
FF Hamdan et al.
BIOCHEMISTRY (2002)
Conformational changes that occur during M3 muscarinic acetylcholine receptor activation probed by the use of an in situ disulfide cross-linking strategy
SDC Ward et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Structure and function in rhodopsin: Mapping light-dependent changes in distance between residue 65 in helix TM1 and residues in the sequence 306-319 at the cytoplasmic end of helix TM7 and in helix H8
C Altenbach et al.
BIOCHEMISTRY (2001)
Structure and function in rhodopsin: Mapping light-dependent changes in distance between residue 316 in helix 8 and residues in the sequence 60-75, covering the cytoplasmic end of helices TM1 and TM2 and their connection loop CL1
C Altenbach et al.
BIOCHEMISTRY (2001)
Single-molecule spectroscopy of the β2 adrenergic receptor:: Observation of conformational substates in a membrane protein
G Peleg et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Functionally different agonists induce distinct conformations in the G protein coupling domain of the β2 adrenergic receptor
P Ghanouni et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Agonist-induced conformational changes in the G-protein-coupling domain of the β2 adrenergic receptor
P Ghanouni et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Solution 19F nuclear Overhauser effects in structural studies of the cytoplasmic domain of mammalian rhodopsin
MC Loewen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Conformation of a peptide ligand bound to its G-protein coupled receptor
H Inooka et al.
NATURE STRUCTURAL BIOLOGY (2001)
Structure and dynamics of micelle-bound neuropeptide Y: Comparison with unligated NPY and implications for receptor selection
R Bader et al.
JOURNAL OF MOLECULAR BIOLOGY (2001)
The renaissance of fluorescence resonance energy transfer
PR Selvin
NATURE STRUCTURAL BIOLOGY (2000)
Identifying conformational changes with site-directed spin labeling
WL Hubbell et al.
NATURE STRUCTURAL BIOLOGY (2000)