Journal
MOLECULES
Volume 25, Issue 18, Pages -Publisher
MDPI
DOI: 10.3390/molecules25184069
Keywords
bacterial cellulose; skin wounds; antimicrobial effect; drug delivery; dressings
Funding
- Operational Programme Human Capital of the Ministry of European Funds [51668/09.07.2019, 124705]
- University POLITEHNICA of Bucharest
- Ministry of Education and Research [638/12.03.2014, SMIS-CSNR 48652]
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The use of bacterial cellulose (BC) in skin wound treatment is very attractive due to its unique characteristics. These dressings' wet environment is an important feature that ensures efficient healing. In order to enhance the antimicrobial performances, bacterial-cellulose dressings were loaded with amoxicillin and bacitracin as antibacterial agents. Infrared characterization and thermal analysis confirmed bacterial-cellulose binding to the drug. Hydration capacity showed good hydrophilicity, an efficient dressing's property. The results confirmed the drugs' presence in the bacterial-cellulose dressing's structure as well as the antimicrobial efficiency against Staphylococcus aureus and Escherichia coli. The antimicrobial assessments were evaluated by contacting these dressings with the above-mentioned bacterial strains and evaluating the growth inhibition of these microorganisms.
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