4.6 Review

Fatty Acid Synthase: An Emerging Target in Cancer

Related references

Note: Only part of the references are listed.
Article Dentistry, Oral Surgery & Medicine

Anticancer properties of the fatty acid synthase inhibitor TVB-3166 on oral squamous cell carcinoma cell lines

Iara Goncalves de Aquino et al.

ARCHIVES OF ORAL BIOLOGY (2020)

Article Chemistry, Medicinal

Orlistat Displays Antitumor Activity and Enhances the Efficacy of Paclitaxel in Human Hepatoma Hep3B Cells

Bang-Jau You et al.

CHEMICAL RESEARCH IN TOXICOLOGY (2019)

Article Oncology

CD36 mediates palmitate acid-induced metastasis of gastric cancer via AKT/GSK-3/-catenin pathway

Jiaomeng Pan et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

Article Multidisciplinary Sciences

Tumor metastasis to lymph nodes requires YAP-dependent metabolic adaptation

Choong-kun Lee et al.

SCIENCE (2019)

Article Cell Biology

FASN activity is important for the initial stages of the induction of senescence

Juan Fafian-Labora et al.

CELL DEATH & DISEASE (2019)

Article Multidisciplinary Sciences

Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis

Kuei-Pin Chung et al.

NATURE COMMUNICATIONS (2019)

Article Multidisciplinary Sciences

In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer

Milica Momcilovic et al.

NATURE (2019)

Article Medicine, General & Internal

New Insight on Solute Carrier Family 27 Member 6 (SLC27A6) in Tumoral and Non-Tumoral Breast Cells

Meng-Chi Yen et al.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2019)

Article Biochemistry & Molecular Biology

Fatty Acid Synthase Contributes to Restimulation-Induced Cell Death of Human CD4 T Cells

Kelsey Voss et al.

FRONTIERS IN MOLECULAR BIOSCIENCES (2019)

Article Medicine, Research & Experimental

Fatty acid synthase mediates EGFR palmitoylation in EGFR mutated non-small cell lung cancer

Azhar Ali et al.

EMBO MOLECULAR MEDICINE (2018)

Article Oncology

The effect of FASN inhibition on the growth and metabolism of a cisplatin-resistant ovarian carcinoma model

Efthymia Papaevangelou et al.

INTERNATIONAL JOURNAL OF CANCER (2018)

Article Biochemistry & Molecular Biology

Adipocyte-induced CD36 expression drives ovarian cancer progression and metastasis

Andras Ladanyi et al.

ONCOGENE (2018)

Article Oncology

Adipocyte-Derived Lipids Mediate Melanoma Progression via FATP Proteins

Maomao Zhang et al.

CANCER DISCOVERY (2018)

Article Biochemistry & Molecular Biology

Solute Carrier Family 27 Member 4 (SLC27A4) Enhances Cell Growth, Migration, and Invasion in Breast Cancer Cells

Meng-Chi Yen et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Biochemistry & Molecular Biology

Anti-Tumorigenic Potential of a Novel Orlistat-AICAR Combination in Prostate Cancer Cells

Clayton Wright et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2017)

Article Multidisciplinary Sciences

Oncogene KRAS activates fatty acid synthase, resulting in specific ERK and lipid signatures associated with lung adenocarcinoma

Arvin M. Gouw et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Multidisciplinary Sciences

Fatty acid synthase cooperates with protrudin to facilitate membrane outgrowth of cellular protrusions

Chuanling Zhang et al.

SCIENTIFIC REPORTS (2017)

Article Cell Biology

Clinical and therapeutic relevance of the metabolic oncogene fatty acid synthase in HER2+breast cancer

Bruna Corominas-Faja et al.

HISTOLOGY AND HISTOPATHOLOGY (2017)

Review Biochemistry & Molecular Biology

Mitochondrial fatty acid synthesis, fatty acids and mitochondrial physiology

Alexander J. Kastaniotis et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2017)

Review Pharmacology & Pharmacy

Recent advances in targeting the fatty acid biosynthetic pathway using fatty acid synthase inhibitors

Thelma S. Angeles et al.

EXPERT OPINION ON DRUG DISCOVERY (2016)

Article Multidisciplinary Sciences

FASN regulates cellular response to genotoxic treatments by increasing PARP-1 expression and DNA repair activity via NF-κB and SP1

Xi Wu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Biochemistry & Molecular Biology

Up-regulation of fatty acid synthase induced by EGFR/ERK activation promotes tumor growth in pancreatic cancer

Yong Bian et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)

Article Multidisciplinary Sciences

Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors

Anneleen Daemen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Meeting Abstract Oncology

First-in-human investigation of the oral first-in-class fatty acid synthase (FASN) inhibitor, TVB-2640.

Andrew Jacob Brenner et al.

JOURNAL OF CLINICAL ONCOLOGY (2015)

Article Pathology

Novel Nuclear Localization of Fatty Acid Synthase Correlates with Prostate Cancer Aggressiveness

Allison A. Madigan et al.

AMERICAN JOURNAL OF PATHOLOGY (2014)

Article Endocrinology & Metabolism

Fatty acid synthase is required for mammary gland development and milk production during lactation

Janel Suburu et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2014)

Article Pharmacology & Pharmacy

Targeting SREBP-1-driven Lipid Metabolism to Treat Cancer

Deliang Guo et al.

CURRENT PHARMACEUTICAL DESIGN (2014)

Article Oncology

Exogenous fatty acid binding protein 4 promotes human prostate cancer cell progression

Hisanori Uehara et al.

INTERNATIONAL JOURNAL OF CANCER (2014)

Article Medicine, Research & Experimental

Positive feedback regulation between Akt phosphorylation and fatty acid synthase expression in osteosarcoma

Heng Wang et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2014)

Article Biochemistry & Molecular Biology

Inhibition of fatty acid synthase suppresses U-2 OS cell invasion and migration via downregulating the activity of HER2/PI3K/AKT signaling pathway in vitro

Tao Fang Wang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2013)

Article Oncology

Enhanced antitumor activity of cerulenin combined with oxaliplatin in human colon cancer cells

Risa Shiragami et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2013)

Article Biochemistry & Molecular Biology

Nutrient-dependent phosphorylation channels lipid synthesis to regulate PPARα

Anne P. L. Jensen-Urstad et al.

JOURNAL OF LIPID RESEARCH (2013)

Article Biochemistry & Molecular Biology

Fatty acid synthase inhibitor orlistat induces apoptosis in T cell lymphoma: Role of cell survival regulatory molecules

Shiva Kant et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2012)

Review Biochemistry & Molecular Biology

Fatty acid synthase and liver triglyceride metabolism: Housekeeper or messenger?

Anne P. L. Jensen-Urstad et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2012)

Article Biochemistry & Molecular Biology

Identification of a New Fatty Acid Synthesis-Transport Machinery at the Peroxisomal Membrane

Merle Hillebrand et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Multidisciplinary Sciences

Blockade of Fatty Acid Synthase Triggers Significant Apoptosis in Mantle Cell Lymphoma

Pascal Gelebart et al.

PLOS ONE (2012)

Article Multidisciplinary Sciences

Dysregulation of fatty acid synthesis and glycolysis in non-Hodgkin lymphoma

Aadra P. Bhatt et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Review Biochemistry & Molecular Biology

Hallmarks of Cancer: The Next Generation

Douglas Hanahan et al.

Article Medicine, Research & Experimental

Inhibition of fatty acid synthase in melanoma cells activates the intrinsic pathway of apoptosis

Karina G. Zecchin et al.

LABORATORY INVESTIGATION (2011)

Review Pharmacology & Pharmacy

The peroxisome proliferator-activated receptor: A family of nuclear receptors role in various diseases

Sandeep Tyagi et al.

JOURNAL OF ADVANCED PHARMACEUTICAL TECHNOLOGY & RESEARCH (2011)

Article Biochemistry & Molecular Biology

Roles of Peroxisome Proliferator-Activated Receptor-α and -γ in the Development of Non-Small Cell Lung Cancer

Ming-Yue Li et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2010)

Article Biochemistry & Molecular Biology

Mitochondrial fatty acid synthesis and respiration

J. Kalervo Hiltunen et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2010)

Review Oncology

Fatty acid synthase as a potential therapeutic target in cancer

Richard Flavin et al.

FUTURE ONCOLOGY (2010)

Article Biochemistry & Molecular Biology

CD36 Is a Novel Serum Amyloid A (SAA) Receptor Mediating SAA Binding and SAA-induced Signaling in Human and Rodent Cells

Irina N. Baranova et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Review Cardiac & Cardiovascular Systems

Transcriptional control of mitochondrial biogenesis:: the central role of PGC-1α

Renee Ventura-Clapier et al.

CARDIOVASCULAR RESEARCH (2008)

Review Biotechnology & Applied Microbiology

Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets

Masato Furuhashi et al.

NATURE REVIEWS DRUG DISCOVERY (2008)

Review Cell Biology

Regulation of mitochondrial fusion and division

Kara L. Cerveny et al.

TRENDS IN CELL BIOLOGY (2007)

Article Medicine, Research & Experimental

Brain fatty acid synthase activates PPARα to maintain energy homeostasis

Manu V. Chakravarthy et al.

JOURNAL OF CLINICAL INVESTIGATION (2007)

Article Biochemistry & Molecular Biology

Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat

Charles W. Pemble et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2007)

Article Medicine, General & Internal

PPARs and their metabolic modulation: new mechanisms for transcriptional regulation?

W. Ahmed et al.

JOURNAL OF INTERNAL MEDICINE (2007)

Article Biotechnology & Applied Microbiology

Genome-wide changes accompanying knockdown of fatty acid synthase in breast cancer

Lynn M. Knowles et al.

BMC GENOMICS (2007)

Article Cell Biology

Metabolic regulation in the lactating mammary gland: a lipid synthesizing machine

Michael C. Rudolph et al.

PHYSIOLOGICAL GENOMICS (2007)

Review Endocrinology & Metabolism

Androgen activation of the sterol regulatory element-binding protein pathway: Current insights

Hannelore V. Heemers et al.

MOLECULAR ENDOCRINOLOGY (2006)

Article Biochemistry & Molecular Biology

C75, a fatty acid synthase inhibitor, modulates AMP-activated protein kinase to alter neuronal energy metabolism

LE Landree et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Review Biochemistry & Molecular Biology

SREBP transcription factors:: master regulators of lipid homeostasis

D Eberlé et al.

BIOCHIMIE (2004)

Article Biochemistry & Molecular Biology

Structure and function of animal fatty acid synthase

SS Chirala et al.

LIPIDS (2004)

Review Biochemistry & Molecular Biology

Metabolism and signaling activities of nuclear lipids

AM Martelli et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2004)

Article Multidisciplinary Sciences

Fatty acid synthesis is essential in embryonic development:: Fatty acid synthase null mutants and most of the heterozygotes die in utero

SS Chirala et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Review Biochemistry & Molecular Biology

New insights into the structure and function of fatty acid-binding proteins

AW Zimmerman et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2002)

Review Biochemistry & Molecular Biology

The hallmarks of cancer

D Hanahan et al.