Journal
MOLECULES
Volume 25, Issue 20, Pages -Publisher
MDPI
DOI: 10.3390/molecules25204781
Keywords
lipid nanoparticles; solvent injection; entrapment efficiency; diffusion; aqueous phase; organic phase; solid lipid; liquid lipid; emulsifier
Funding
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Korean Ministry of Science, ICT & Future Planning [NRF-2019R1F1A1058103]
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Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) have emerged as potential drug delivery systems for various applications that are produced from physiological, biodegradable, and biocompatible lipids. The methods used to produce SLNs and NLCs have been well investigated and reviewed, but solvent injection method provides an alternative means of preparing these drug carriers. The advantages of solvent injection method include a fast production process, easiness of handling, and applicability in many laboratories without requirement of complicated instruments. The effects of formulations and process parameters of this method on the characteristics of the produced SLNs and NLCs have been investigated in several studies. This review describes the methods currently used to prepare SLNs and NLCs with focus on solvent injection method. We summarize recent development in SLNs and NLCs production using this technique. In addition, the effects of solvent injection process parameters on SLNs and NLCs characteristics are discussed.
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