4.5 Review

Notch1 in Cancer Therapy: Possible Clinical Implications and Challenges

Related references

Note: Only part of the references are listed.
Article Cell Biology

Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition

Roger A. Habets et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

Review Hematology

Therapeutic Targeting of Notch Signaling Pathway in Hematological Malignancies

Claudia Sorrentino et al.

MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES (2019)

Article Immunology

Leukemia-specific delivery of mutant NOTCH1 targeted therapy

Giovanni Roti et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2018)

Article Biochemistry & Molecular Biology

Inhibition of Notch signaling pathway using gamma-secretase inhibitor delivered by a low dose of Triton-X100 in cultured oral cancer cells

Aklima Nasrin et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

Article Biochemistry & Molecular Biology

Mir-34a-5p Mediates Cross-Talk between M2 Muscarinic Receptors and Notch-1/EGFR Pathways in U87MG Glioblastoma Cells: Implication in Cell Proliferation

Maria Di Bari et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Oncology

Gamma Secretase Inhibition by BMS-906024 Enhances Efficacy of Paclitaxel in Lung Adenocarcinoma

Katherine M. Morgan et al.

MOLECULAR CANCER THERAPEUTICS (2017)

Article Public, Environmental & Occupational Health

Targeted inhibition of Notch1 gene enhances the killing effects of Paclitaxel on triple-negative breast cancer cells

Yu-Fu Zhou et al.

ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE (2017)

Article Oncology

Notch1 ablation radiosensitizes glioblastoma cells

Na Han et al.

ONCOTARGET (2017)

Article Medicine, Research & Experimental

γ-Secretase inhibitors in cancer clinical trials are pharmacologically and functionally distinct

Yong Ran et al.

EMBO MOLECULAR MEDICINE (2017)

Review Oncology

The Notch-1 receptor in prostate tumorigenesis

Rebecca O'Brien et al.

CANCER TREATMENT REVIEWS (2017)

Article Oncology

Endothelial Notch1 Activity Facilitates Metastasis

Elfriede Wieland et al.

CANCER CELL (2017)

Article Cell Biology

miR-124 interacts with the Notch1 signalling pathway and has therapeutic potential against gastric cancer

Lei Jiang et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2016)

Article Oncology

Targeting Notch to overcome radiation resistance

Sanaz Yahyanejad et al.

ONCOTARGET (2016)

Article Oncology

Notch1 controls cell chemoresistance in small cell lung carcinoma cells

Wael Abdo Hassan et al.

THORACIC CANCER (2016)

Article Medicine, Research & Experimental

Paeoniflorin inhibits proliferation and invasion of breast cancer cells through suppressing Notch-1 signaling pathway

Qiang Zhang et al.

BIOMEDICINE & PHARMACOTHERAPY (2016)

Review Medicine, General & Internal

Cancer stem cell signaling pathways

William H. Matsui

MEDICINE (2016)

Article Biochemistry & Molecular Biology

Combined inhibition of DDR1 and Notch signaling is a therapeutic strategy for KRAS-driven lung adenocarcinoma

Chiara Ambrogio et al.

NATURE MEDICINE (2016)

Review Genetics & Heredity

Role of non-coding sequence variants in cancer

Ekta Khurana et al.

NATURE REVIEWS GENETICS (2016)

Article Chemistry, Medicinal

BMS-871: A novel orally active pan-Notch inhibitor as an anticancer agent

Weifang Shan et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2015)

Article Oncology

Notch1 pathway in adrenocortical carcinomas: correlations with clinical outcome

Cristina L. Ronchi et al.

ENDOCRINE-RELATED CANCER (2015)

Article Biochemistry & Molecular Biology

Notch-1 Promotes Stemness and Epithelial to Mesenchymal Transition in Colorectal Cancer

Alexander W. Fender et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2015)

Article Medicine, Research & Experimental

Notch promotes recurrence of dormant tumor cells following HER2/neu-targeted therapy

Daniel L. Abravanel et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

Article Oncology

NOTCH1 and FBXW7 Mutations Favor Better Outcome in Pediatric South Indian T-Cell Acute Lymphoblastic Leukemia

Valliyammai Natarajan et al.

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY (2015)

Article Biotechnology & Applied Microbiology

Prognostic value of Notch-1 expression in hepatocellular carcinoma: a meta-analysis

Tao Wu et al.

ONCOTARGETS AND THERAPY (2015)

Editorial Material Oncology

New, Tolerable gamma-Secretase Inhibitor Takes Desmoid Down a Notch

Dennis P. M. Hughes et al.

CLINICAL CANCER RESEARCH (2015)

Article Multidisciplinary Sciences

Expression of Notch1 Correlates with Breast Cancer Progression and Prognosis

Xun Yuan et al.

PLOS ONE (2015)

Article Cell Biology

Silencing of Jagged1 inhibits cell growth and invasion in colorectal cancer

Y. Dai et al.

CELL DEATH & DISEASE (2014)

Article Medicine, Research & Experimental

A Novel SERCA Inhibitor Demonstrates Synergy with Classic SERCA Inhibitors and Targets Multidrug-Resistant AML

Nicholas P. Bleeker et al.

MOLECULAR PHARMACEUTICS (2013)

Article Oncology

Notch activation stimulates migration of breast cancer cells and promotes tumor growth

Victoria Bolos et al.

BREAST CANCER RESEARCH (2013)

Article Pharmacology & Pharmacy

β,β-Dimethylacrylshikonin exerts antitumor activity via Notch-1 signaling pathway in vitro and in vivo

Shao Zhen-Jun et al.

BIOCHEMICAL PHARMACOLOGY (2012)

Article Oncology

A phase II study of RO4929097 in metastatic colorectal cancer

Jonathan R. Strosberg et al.

EUROPEAN JOURNAL OF CANCER (2012)

Article Oncology

Honokiol in Combination with Radiation Targets Notch Signaling to Inhibit Colon Cancer Stem Cells

Sivapriya Ponnurangam et al.

MOLECULAR CANCER THERAPEUTICS (2012)

Article Biochemistry & Molecular Biology

Gamma-secretase inhibitors target tumor-initiating cells in a mouse model of ERBB2 breast cancer

M. Kondratyev et al.

ONCOGENE (2012)

Article Multidisciplinary Sciences

Maintenance of hormone responsiveness in luminal breast cancers by suppression of Notch

James M. Haughian et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Review Cell Biology

Notch receptor-ligand binding and activation: Insights from molecular studies

Chandramouli R. Chillakuri et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2012)

Article Biochemical Research Methods

Uncovering MicroRNA and Transcription Factor Mediated Regulatory Networks in Glioblastoma

Jingchun Sun et al.

PLOS COMPUTATIONAL BIOLOGY (2012)

Article Oncology

Overexpression of Galectin-3 and its clinical significance in ovarian carcinoma

Min Kyu Kim et al.

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY (2011)

Review Neurosciences

The Many Substrates of Presenilin/gamma-Secretase

Annakaisa Haapasalo et al.

JOURNAL OF ALZHEIMERS DISEASE (2011)

Article Multidisciplinary Sciences

Notch1 regulates the expression of the multidrug resistance gene ABCC1/MRP1 in cultured cancer cells

Sungpil Cho et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Oncology

Notch-1 Inhibition by Withaferin-A: A Therapeutic Target against Colon Carcinogenesis

Srinivas Koduru et al.

MOLECULAR CANCER THERAPEUTICS (2010)

Article Multidisciplinary Sciences

Therapeutic antibody targeting of individual Notch receptors

Yan Wu et al.

NATURE (2010)

Article Biochemistry & Molecular Biology

Notch-1 Signaling Is Lost in Prostate Adenocarcinoma and Promotes PTEN Gene Expression

Jarrett T. Whelan et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2009)

Article Biochemistry & Molecular Biology

Selective Use of ADAM10 and ADAM17 in Activation of Notch1 Signaling

Esra Cagavi Bozkulak et al.

MOLECULAR AND CELLULAR BIOLOGY (2009)

Article Multidisciplinary Sciences

Direct inhibition of the NOTCH transcription factor complex

Raymond E. Moellering et al.

NATURE (2009)

Article Biochemistry & Molecular Biology

gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia

Pedro J. Real et al.

NATURE MEDICINE (2009)

Article Education, Scientific Disciplines

The role of NOTCH1 signaling in T-ALL

A. A. Ferrando

Hematology-American Society of Hematology Education Program (2009)

Review Chemistry, Medicinal

Therapeutic potential of gamma-secretase inhibitors and modulators

Bruno P. Imbimbo

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2008)

Review Cell Biology

The Notch pathway in prostate development and cancer

Kevin G. Leong et al.

DIFFERENTIATION (2008)

Article Medicine, Research & Experimental

PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability

Ana Silva et al.

JOURNAL OF CLINICAL INVESTIGATION (2008)

Article Immunology

Delta-like 4 is indispensable in thymic environment specific for T cell development

Katsuto Hozumi et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2008)

Article Biochemistry & Molecular Biology

Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia

Teresa Palomero et al.

NATURE MEDICINE (2007)

Review Oncology

Notch signaling, gamma-secretase inhibitors, and cancer therapy

Ie-Ming Shih et al.

CANCER RESEARCH (2007)

Article Multidisciplinary Sciences

Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis

Irene Noguera-Troise et al.

NATURE (2006)

Article Multidisciplinary Sciences

Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis

John Ridgway et al.

NATURE (2006)

Article Oncology

The response of CD24-/low/CD44+ breast cancer-initiating cells to radiation

Tiffany M. Phillips et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2006)

Article Biochemistry & Molecular Biology

Notch1 contributes to mouse T-cell leukemia by directly inducing the expression of c-myc

Vishva Mitra Sharma et al.

MOLECULAR AND CELLULAR BIOLOGY (2006)

Review Cell Biology

Physiology and pathology of Notch signalling system

S Bianchi et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2006)

Article Dermatology

Notch and NOXA-related pathways in melanoma cells

BJ Nickoloff et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS (2005)

Article Pharmacology & Pharmacy

Inhibition of angiogenesis and tumor growth by β and γ-secretase inhibitors

D Paris et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2005)

Article Multidisciplinary Sciences

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

AP Weng et al.

SCIENCE (2004)

Article Genetics & Heredity

Notch1 functions as a tumor suppressor in mouse skin

M Nicolas et al.

NATURE GENETICS (2003)

Article Biochemistry & Molecular Biology

Presenilin-1 and-2 are molecular targets for γ-secretase inhibitors

D Seiffert et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)