Journal
MOLECULAR BIOLOGY REPORTS
Volume 47, Issue 9, Pages 7209-7228Publisher
SPRINGER
DOI: 10.1007/s11033-020-05709-8
Keywords
Cancer; Marine invertebrates; Bioactive lead compounds; Reactive oxygen species (ROS); Antioxidants
Categories
Funding
- DST-INSPIRE, Department of Science and Technology, Government of India [IF180167]
- Council of Scientific & Industrial Research (CSIR), Government of India [37(1715)/18/EMR-II]
Ask authors/readers for more resources
Marine invertebrates are extremely diverse, largely productive, untapped oceanic resources with chemically unique bioactive lead compound contributing a wide range of screening for the discovery of anticancer compounds. The lead compounds have unfurled an extensive array of pharmacological properties owing to the presence of polyphenols, alkaloids, terpenoids and other secondary metabolites. The antioxidant, immunomodulatory and anti-tumor activities exhibited, are possibly regulated by the apoptosis induction, scavenging of ROS and modulation of cellular signaling pathways to defy the cellular deafness during carcinogenesis. Despite the enriched bioactive compounds, the marine invertebrates are largely unexplored as identification, screening, pre-clinical and clinical assessment of lead compounds and their synthetic analogs remain a major task to be solved. In the current review, we focus on the principle strategy and underlying mechanisms deployed by the bioactive anticancer compounds derived from marine invertebrates to combat cancer with special insight into the cell death mechanism.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available