Journal
MITOCHONDRION
Volume 55, Issue -, Pages 164-173Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2020.10.003
Keywords
Mitochondrial calcium homeostasis; UCP2; MICU1; PRMT1; MCU
Categories
Funding
- Austrian Science Fund (FWF)
- Doctoral Program Metabolic and Cardiovascular Disease [DK-MCD W1226]
- Nikon Austria within the Nikon Center of Excellence, Graz
- MEFO-Graz
- FWF [J4205-B27]
- Austrian Science Funds [DK-MCD W1226]
- Medical University of Graz
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Considering the versatile functions attributed to uncoupling protein 2 (UCP2) in health and disease, a profound understanding of the protein's molecular actions under physiological and pathophysiological conditions is indispensable. This review aims to revisit and shed light on the fundamental molecular functions of UCP2 in mitochondria, with particular emphasis on its intricate role in regulating mitochondrial calcium (Ca2+) uptake. UCP2's modulating effect on various vital processes in mitochondria makes it a crucial regulator of mitochondrial homeostasis in health and disease.
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