Journal
MICROCHEMICAL JOURNAL
Volume 160, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.microc.2020.105609
Keywords
Zinc tetrahydroxyphthalocyanine; Reduced graphene oxide; Electrochemical sensor; Acetaminophen; Non-covalent functionalization
Categories
Funding
- National Natural Science Foundation of China [51703259]
- Henan University of Chinese Medicine [00104358, 03301232]
- Key scientific research project of Henan province [18B360007]
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A new amplified signal strategy for acetaminophen electrochemical sensor was developed using a soluble zinc tetrahydroxyphthalocyanine-reduced graphene oxide nanocomposite as an improved electrode material. The sensor showed a sensitive and selective electroanalytical method for AC, with linear response in different concentration ranges and excellent selectivity, reproducibility, and long-term stability.
A new amplified signal strategy for acetaminophen (AC) electrochemical sensor was explored by soluble zinc tetrahydroxyphthalocyanine-reduced graphene oxide nanocomposite as an improved electrode material via non-covalent functionalization. The electrochemical signal of AC was amplified by the remarkably increased electroactive surface area of the nanocomposite-modified glassy carbon electrode. Moreover, the synergistic enrichment effect can be achieved by the adsorption of pi-pi stacking and hydrogen bonding of hydroxyl groups. The prominent electrocatalytic effect toward AC oxidation were examined systematically on the proposed sensor and a sensitive and selective electroanalytical method for AC was developed. Under optimized conditions, the electrochemical response of the sensor exhibited a linear dependence on the concentration of AC ranging from 0.03 to 100 mu M and 100 to 800 mu M with a detection limit of 10 nM (S/N = 3). The proposed sensor with excellent selectivity, reproducibility and long-term stability for AC sensing was successfully applied for AC determination in drug formulation and human urine samples.
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