Related references
Note: Only part of the references are listed.Evaluation of an octahydroisochromene scaffold used as a novel SARS 3CL protease inhibitor
Shin-ichiro Yoshizawa et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2020)
Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro
Manli Wang et al.
CELL RESEARCH (2020)
Learning from the Past: Possible Urgent Prevention and Treatment Options for Severe Acute Respiratory Infections Caused by 2019-nCoV
Jared S. Morse et al.
CHEMBIOCHEM (2020)
Recent discovery and development of inhibitors targeting coronaviruses
Thanigaimalai Pillaiyar et al.
DRUG DISCOVERY TODAY (2020)
Coronavirus infections and immune responses
Geng Li et al.
JOURNAL OF MEDICAL VIROLOGY (2020)
α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment
Linlin Zhang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
A Review of Small Molecule Inhibitors and Functional Probes of Human Cathepsin L
Dibyendu Dana et al.
MOLECULES (2020)
A new coronavirus associated with human respiratory disease in China
Fan Wu et al.
NATURE (2020)
A pneumonia outbreak associated with a new coronavirus of probable bat origin
Peng Zhou et al.
NATURE (2020)
Coronavirus puts drug repurposing on the fast track
Charlotte Harrison
NATURE BIOTECHNOLOGY (2020)
COVID-19 and the cardiovascular system
Ying-Ying Zheng et al.
NATURE REVIEWS CARDIOLOGY (2020)
Therapeutic options for the 2019 novel coronavirus (2019-nCoV)
Guangdi Li et al.
NATURE REVIEWS DRUG DISCOVERY (2020)
First Case of 2019 Novel Coronavirus in the United States
Michelle L. Holshue et al.
NEW ENGLAND JOURNAL OF MEDICINE (2020)
A Novel Coronavirus from Patients with Pneumonia in China, 2019
Na Zhu et al.
NEW ENGLAND JOURNAL OF MEDICINE (2020)
Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2
Renhong Yan et al.
SCIENCE (2020)
Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation
Daniel Wrapp et al.
SCIENCE (2020)
Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission
Xintian Xu et al.
SCIENCE CHINA-LIFE SCIENCES (2020)
Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs
Sangeun Jeon et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2020)
Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein
Alexandra C. Walls et al.
CELL (2020)
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Markus Hoffmann et al.
CELL (2020)
In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
Xueting Yao et al.
CLINICAL INFECTIOUS DISEASES (2020)
Interactions of coronaviruses with ACE2, angiotensin II, and RAS inhibitors-lessons from available evidence and insights into COVID-19
Hisashi Kai et al.
HYPERTENSION RESEARCH (2020)
New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19?
Christian A. Devaux et al.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2020)
Joint HFSA/ACC/AHA Statement Addresses Concerns Re: Using RAAS Antagonists in COVID-19
Biykem Bozkurt et al.
JOURNAL OF CARDIAC FAILURE (2020)
COVID-19 spike-host cell receptor GRP78 binding site prediction
Ibrahim M. Ibrahim et al.
JOURNAL OF INFECTION (2020)
Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease
Wenhao Dai et al.
SCIENCE (2020)
Structure of the RNA-dependent RNA polymerase from COVID-19 virus
Yan Gao et al.
SCIENCE (2020)
Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors
Linlin Zhang et al.
SCIENCE (2020)
Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir
Wanchao Yin et al.
SCIENCE (2020)
An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice
Timothy P. Sheahan et al.
SCIENCE TRANSLATIONAL MEDICINE (2020)
Covid-19: six million doses of hydroxychloroquine donated to US despite lack of evidence
Elisabeth Mahase
BMJ-BRITISH MEDICAL JOURNAL (2020)
Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection?
Lei Fang et al.
LANCET RESPIRATORY MEDICINE (2020)
Research and Development on Therapeutic Agents and Vaccines for COVID-19 and Related Human Coronavirus Diseases
Cynthia Liu et al.
ACS CENTRAL SCIENCE (2020)
Chemistry and Biology of SARS-CoV-2
Alexander Domling et al.
CHEM (2020)
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
David E. Gordon et al.
NATURE (2020)
Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors
Zhenming Jin et al.
NATURE (2020)
Audio Interview: New Research on Possible Treatments for Covid-19
Eric J. Rubin et al.
NEW ENGLAND JOURNAL OF MEDICINE (2020)
Structural elucidation of SARS-CoV-2 vital proteins: Computational methods reveal potential drug candidates against main protease, Nsp12 polymerase and Nsp13 helicase
Muhammad Usman Mirza et al.
JOURNAL OF PHARMACEUTICAL ANALYSIS (2020)
A medicinal chemistry perspective of drug repositioning: Recent advances and challenges in drug discovery
Thanigaimalai Pillaiyar et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)
Renin-Angiotensin System Blockers and the COVID-19 Pandemic At Present There Is No Evidence to Abandon Renin-Angiotensin System Blockers
A. H. Jan Danser et al.
HYPERTENSION (2020)
Review of: Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial Gautret et al 2010, DOI:10.1016/j.ijantimicag.2020.105949
Frits R. Rosendaal
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2020)
A systematic review on the ef ficacy and safety of chloroquine for the treatment of COVID-19
Andrea Cortegiani et al.
JOURNAL OF CRITICAL CARE (2020)
Preliminary Virtual Screening Studies to Identify GRP78 Inhibitors Which May Interfere with SARS-CoV-2 Infection
Andreia Palmeira et al.
PHARMACEUTICALS (2020)
Efficacy of hydroxychloroquine for post-exposure prophylaxis to prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among adults exposed to coronavirus disease (COVID-19): a structured summary of a study protocol for a randomised controlled trial
Ruanne V. Barnabas et al.
TRIALS (2020)
The stress-inducible molecular chaperone GRP78 as potential therapeutic target for coronavirus infection
Dat P. Ha et al.
JOURNAL OF INFECTION (2020)
Should COVID-19 Concern Nephrologists? Why and to What Extent? The Emerging Impasse of Angiotensin Blockade
Luca Perico et al.
NEPHRON (2020)
A small-molecule fusion inhibitor of influenza virus is orally active in mice
Maria J. P. van Dongen et al.
SCIENCE (2019)
A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike
Shuai Xia et al.
SCIENCE ADVANCES (2019)
Evaluation of a non-prime site substituent and warheads combined with a decahydroisoquinolin scaffold as a SARS 3CL protease inhibitor
Kouji Ohnishi et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2019)
Origin and evolution of pathogenic coronaviruses
Jie Cui et al.
NATURE REVIEWS MICROBIOLOGY (2019)
SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection
Nils C. Gassen et al.
NATURE COMMUNICATIONS (2019)
Disulfiram can inhibit MERS and SARS coronavirus papain-like proteases via different modes
Min-Han Lin et al.
ANTIVIRAL RESEARCH (2018)
Galidesivir limits Rift Valley fever virus infection and disease in Syrian golden hamsters
Jonna B. Westover et al.
ANTIVIRAL RESEARCH (2018)
Targeting the renin-angiotensin system as novel therapeutic strategy for pulmonary diseases
Wan Shun Daniel Tan et al.
CURRENT OPINION IN PHARMACOLOGY (2018)
Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element
Anushka C. Galasiti Kankanamalage et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)
Coronavirus S protein-induced fusion is blocked prior to hemifusion by Abl kinase inhibitors
Jeanne M. Sisk et al.
JOURNAL OF GENERAL VIROLOGY (2018)
Saracatinib Inhibits Middle East Respiratory Syndrome-Coronavirus Replication In Vitro
Jin Soo Shin et al.
VIRUSES-BASEL (2018)
Structural basis of influenza virus fusion inhibition by the antiviral drug Arbidol
Rameshwar U. Kadam et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Evaluation of polyphenols from Broussonetia papyrifera as coronavirus protease inhibitors
Ji-Young Park et al.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2017)
Safety and efficacy of ebselen for the prevention of noise-induced hearing loss: a randomised, double-blind, placebo-controlled, phase 2 trial
Jonathan Kil et al.
LANCET (2017)
Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses
Timothy P. Sheahan et al.
SCIENCE TRANSLATIONAL MEDICINE (2017)
Molecular Evolution of Human Coronavirus Genomes
Diego Forni et al.
TRENDS IN MICROBIOLOGY (2017)
Identification and evaluation of potent Middle East respiratory syndrome coronavirus (MERS-CoV) 3CLPro inhibitors
Vathan Kumar et al.
ANTIVIRAL RESEARCH (2017)
Targeting endosomal acidification by chloroquine analogs as a promising strategy for the treatment of emerging viral diseases
Md Abdul Alim Al-Bari
PHARMACOLOGY RESEARCH & PERSPECTIVES (2017)
Chalcones isolated from Angelica keiskei inhibit cysteine proteases of SARS-CoV
Ji-Young Park et al.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2016)
Identification, synthesis and evaluation of SARS-CoV and MERS-CoV 3C-like protease inhibitors
Vathan Kumar et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2016)
Glycopeptide Antibiotics Potently Inhibit Cathepsin L in the Late Endosome/Lysosome and Block the Entry of Ebola Virus, Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)
Nan Zhou et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
An Overview of Severe Acute Respiratory Syndrome-Coronavirus (SARS-CoV) 3CL Protease Inhibitors: Peptidomimetics and Small Molecule Chemotherapy
Thanigaimalai Pillaiyar et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Abelson Kinase Inhibitors Are Potent Inhibitors of Severe Acute Respiratory Syndrome Coronavirus and Middle East Respiratory Syndrome Coronavirus Fusion
Christopher M. Coleman et al.
JOURNAL OF VIROLOGY (2016)
Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys
Travis K. Warren et al.
NATURE (2016)
Zika virus cell tropism in the developing human brain and inhibition by azithromycin
Hanna Retallack et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Effects of the potential lithium-mimetic, ebselen, on impulsivity and emotional processing
Charles Masaki et al.
PSYCHOPHARMACOLOGY (2016)
Activation of angiotensin-converting enzyme 2 (ACE2) attenuates allergic airway inflammation in rat asthma model
Vaibhav Shrirang Dhawale et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2016)
Epidemiology, Genetic Recombination, and Pathogenesis of Coronaviruses
Shuo Su et al.
TRENDS IN MICROBIOLOGY (2016)
Structure of Main Protease from Human Coronavirus NL63: Insights for Wide Spectrum Anti-Coronavirus Drug Design
Fenghua Wang et al.
SCIENTIFIC REPORTS (2016)
BCX4430-A broad-spectrum antiviral adenosine nucleoside analog under development for the treatment of Ebola virus disease
Raymond Taylor et al.
JOURNAL OF INFECTION AND PUBLIC HEALTH (2016)
Inhibitor Recognition Specificity of MERS-CoV Papain-like Protease May Differ from That of SARS-CoV
Hyun Lee et al.
ACS CHEMICAL BIOLOGY (2015)
Protease inhibitors targeting coronavirus and filovirus entry
Yanchen Zhou et al.
ANTIVIRAL RESEARCH (2015)
Thiopurine analogs and mycophenolic acid synergistically inhibit the papain-like protease of Middle East respiratory syndrome coronavirus
Kai-Wen Cheng et al.
ANTIVIRAL RESEARCH (2015)
Fused-ring structure of decahydroisoquinolin as a novel scaffold for SARS 3CL protease inhibitors
Yasuhiro Shimamoto et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2015)
Early Administration of Azithromycin and Prevention of Severe Lower Respiratory Tract Illnesses in Preschool Children With a History of Such Illnesses A Randomized Clinical Trial
Leonard B. Bacharier et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2015)
Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CLpro) IMPLICATIONS FOR nsp5 REGULATION AND THE DEVELOPMENT OF ANTIVIRALS
Sakshi Tomar et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
Protective Effect of Intranasal Regimens Containing Peptidic Middle East Respiratory Syndrome Coronavirus Fusion Inhibitor Against MERS-CoV Infection
Rudragouda Channappanavar et al.
JOURNAL OF INFECTIOUS DISEASES (2015)
Human Coronavirus HKU1 Spike Protein Uses O-Acetylated Sialic Acid as an Attachment Receptor Determinant and Employs Hemagglutinin-Esterase Protein as a Receptor-Destroying Enzyme
Xingchuan Huang et al.
JOURNAL OF VIROLOGY (2015)
ATP1A1-Mediated Src Signaling Inhibits Coronavirus Entry into Host Cells
Christine Burkard et al.
JOURNAL OF VIROLOGY (2015)
SOUTH KOREA MERS cases spotlight lack of research
Declan Butler
NATURE (2015)
Evaluation of Ebola Virus Inhibitors for Drug Repurposing
Peter B. Madrid et al.
ACS INFECTIOUS DISEASES (2015)
Testing of Middle East Respiratory Syndrome Coronavirus Replication Inhibitors for the Ability To Block Viral Entry
Qi Liu et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2015)
Screening of an FDA-Approved Compound Library Identifies Four Small-Molecule Inhibitors of Middle East Respiratory Syndrome Coronavirus Replication in Cell Culture
Adriaan H. de Wilde et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2014)
Repurposing of Clinically Developed Drugs for Treatment of Middle East Respiratory Syndrome Coronavirus Infection
Julie Dyall et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2014)
Synthesis, modification and docking studies of 5-sulfonyl isatin derivatives as SARS-CoV 3C-like protease inhibitors
Wei Liu et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2014)
Host Species Restriction of Middle East Respiratory Syndrome Coronavirus through Its Receptor, Dipeptidyl Peptidase 4
Neeltje van Doremalen et al.
JOURNAL OF VIROLOGY (2014)
Identification, Synthesis, and Evaluation of New Neuraminidase Inhibitors
Vathan Kumar et al.
ORGANIC LETTERS (2014)
One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities
Lorenzo Subissi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Potent Neutralization of MERS-CoV by Human Neutralizing Monoclonal Antibodies to the Viral Spike Glycoprotein
Liwei Jiang et al.
SCIENCE TRANSLATIONAL MEDICINE (2014)
Nidovirus papain-like proteases: Multifunctional enzymes with protease, deubiquitinating and delSGylating activities
Anna M. Mielech et al.
VIRUS RESEARCH (2014)
Structure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor
Lu Lu et al.
NATURE COMMUNICATIONS (2014)
Angiotensin-converting enzyme 2 (ACE2) mediates influenza H7N9 virus-induced acute lung injury
Penghui Yang et al.
SCIENTIFIC REPORTS (2014)
Coronavirus Cell Entry Occurs through the Endo-/Lysosomal Pathway in a Proteolysis-Dependent Manner
Christine Burkard et al.
PLOS PATHOGENS (2014)
From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses
Rolf Hilgenfeld et al.
ANTIVIRAL RESEARCH (2013)
Design and synthesis of new tripeptide-type SARS-CoV 3CL protease inhibitors containing an electrophilic arylketone moiety
Sho Konno et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2013)
Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding
Mark Turlington et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2013)
Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4
Nianshuang Wang et al.
CELL RESEARCH (2013)
Phenotypic vs. Target-Based Drug Discovery for First-in-Class Medicines
D. C. Swinney
CLINICAL PHARMACOLOGY & THERAPEUTICS (2013)
Haemoconcentration, renal function, and post-discharge outcomes among patients hospitalized for heart failure with reduced ejection fraction: insights from the EVEREST trial
Stephen J. Greene et al.
EUROPEAN JOURNAL OF HEART FAILURE (2013)
Design, synthesis, and biological evaluation of novel dipeptide-type SARS-CoV 3CL protease inhibitors: Structure-activity relationship study
Pillaiyar Thanigaimalai et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2013)
Development of potent dipeptide-type SARS-CoV 3CL protease inhibitors with novel P3 scaffolds: Design, synthesis, biological evaluation, and docking studies
Pillaiyar Thanigaimalai et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2013)
Anti-SARS coronavirus agents: a patent review (2008-present)
Vathan Kumar et al.
EXPERT OPINION ON THERAPEUTIC PATENTS (2013)
Discovery, Synthesis, And Structure-Based Optimization of a Series of N-(tert-Butyl)-2-(N-arylamido)-2-(pyridin-3-yl) Acetamides (ML188) as Potent Noncovalent Small Molecule Inhibitors of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL Protease
Jon Jacobs et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Middle East Respiratory Syndrome Coronavirus Infection Mediated by the Transmembrane Serine Protease TMPRSS2
Kazuya Shirato et al.
JOURNAL OF VIROLOGY (2013)
Novel Inhibitors of Severe Acute Respiratory Syndrome Coronavirus Entry That Act by Three Distinct Mechanisms
Adeyemi O. Adedeji et al.
JOURNAL OF VIROLOGY (2013)
The Receptor Binding Domain of the New Middle East Respiratory Syndrome Coronavirus Maps to a 231-Residue Region in the Spike Protein That Efficiently Elicits Neutralizing Antibodies
Huihui Mou et al.
JOURNAL OF VIROLOGY (2013)
Assessing Activity and Inhibition of Middle East Respiratory Syndrome Coronavirus Papain-Like and 3C-Like Proteases Using Luciferase-Based Biosensors
Andy Kilianski et al.
JOURNAL OF VIROLOGY (2013)
Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26
Guangwen Lu et al.
NATURE (2013)
Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC
V. Stalin Raj et al.
NATURE (2013)
In-vitro renal epithelial cell infection reveals a viral kidney tropism as a potential mechanism for acute renal failure during Middle East Respiratory Syndrome (MERS) Coronavirus infection
Isabella Eckerle et al.
VIROLOGY JOURNAL (2013)
The newly emerged SARS-Like coronavirus HCoV-EMC also has an Achilles' heel: current effective inhibitor targeting a 3C-like protease
Zhilin Ren et al.
PROTEIN & CELL (2013)
Biochemical characterization of a recombinant SARS coronavirus nsp12 RNA-dependent RNA polymerase capable of copying viral RNA templates
Dae-Gyun Ahn et al.
ARCHIVES OF VIROLOGY (2012)
Tanshinones as selective and slow-binding inhibitors for SARS-CoV cysteine proteases
Ji-Young Park et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2012)
Synthesis and antiviral activity of a series of 1′-substituted 4-aza-7,9-dideazaadenosine C-nucleosides
Aesop Cho et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
Simultaneous Treatment of Human Bronchial Epithelial Cells with Serine and Cysteine Protease Inhibitors Prevents Severe Acute Respiratory Syndrome Coronavirus Entry
Miyuki Kawase et al.
JOURNAL OF VIROLOGY (2012)
Pharmacological treatment of schizophrenia: a critical review of the pharmacology and clinical effects of current and future therapeutic agents
S. Miyamoto et al.
MOLECULAR PSYCHIATRY (2012)
Human Coronaviruses: Insights into Environmental Resistance and Its Influence on the Development of New Antiseptic Strategies
Chloe Geller et al.
VIRUSES-BASEL (2012)
Local Renin-Angiotensin II Systems, Angiotensin-Converting Enzyme and its Homologue ACE2: Their Potential Role in the Pathogenesis of Chronic Obstructive Pulmonary Diseases, Pulmonary Hypertension and Acute Respiratory Distress Syndrome
A. Kaparianos et al.
CURRENT MEDICINAL CHEMISTRY (2011)
Structure-Based Design, Synthesis, and Evaluation of Peptide-Mimetic SARS 3CL Protease Inhibitors
Kenichi Akaji et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Loperamide
Claud Regnard et al.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT (2011)
TACE antagonists blocking ACE2 shedding caused by the spike protein of SARS-CoV are candidate antiviral compounds
Shiori Haga et al.
ANTIVIRAL RESEARCH (2010)
Biflavonoids from Torreya nucifera displaying SARS-CoV 3CLpro inhibition
Young Bae Ryu et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2010)
Synthesis and evaluation of pyrazolone compounds as SARS-coronavirus 3C-like protease inhibitors
R. Ramajayam et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2010)
Severe Acute Respiratory Syndrome Coronavirus Papain-like Novel Protease Inhibitors: Design, Synthesis, Protein-Ligand X-ray Structure and Biological Evaluation
Arun K. Ghosh et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
NMR Structure of the SARS-CoV Nonstructural Protein 7 in Solution at pH 6.5
Margaret A. Johnson et al.
JOURNAL OF MOLECULAR BIOLOGY (2010)
A Small-Molecule Oxocarbazate Inhibitor of Human Cathepsin L Blocks Severe Acute Respiratory Syndrome and Ebola Pseudotype Virus Infection into Human Embryonic Kidney 293T cells
Parag P. Shah et al.
MOLECULAR PHARMACOLOGY (2010)
The RNA polymerase activity of SARS-coronavirus nsp12 is primer dependent
Aartjan J. W. te Velthuis et al.
NUCLEIC ACIDS RESEARCH (2010)
T-705 (favipiravir) and related compounds: Novel broad-spectrum inhibitors of RNA viral infections
Yousuke Furuta et al.
ANTIVIRAL RESEARCH (2009)
New developments for the design, synthesis and biological evaluation of potent SARS-CoV 3CLpro inhibitors
Thomas Regnier et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
Individual and common inhibitors of coronavirus and picornavirus main proteases
Chih-Jung Kuo et al.
FEBS LETTERS (2009)
Structure-Based Design, Synthesis, and Biological Evaluation of a Series of Novel and Reversible Inhibitors for the Severe Acute Respiratory Syndrome-Coronavirus Papain-Like Protease
Arun K. Ghosh et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Amiodarone alters late endosomes and inhibits SARS coronavirus infection at a post-endosomal level
Konrad Stadler et al.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2008)
Molecular docking identifies the binding of 3-chloropyridine moieties specifically to the S1 pocket of SARS-CoV M-pro
Chunying Niu et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2008)
Design, synthesis, and evaluation of trifluoromethyl ketones as inhibitors of SARS-CoV 3CL protease
Yi-Ming Shao et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2008)
Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors
Arun K. Ghosh et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
Aryl methylene ketones and fluorinated methylene ketones as reversible inhibitors for severe acute respiratory syndrome (SARS) 3C-like proteinase
Jianmin Zhang et al.
BIOORGANIC CHEMISTRY (2008)
SARS coronavirus entry into host cells through a novel clathrin- and caveolae-independent endocytic pathway
Hongliang Wang et al.
CELL RESEARCH (2008)
Mouse hepatitis virus type 2 enters cells through a clathrin-mediated Endocytic pathway independent of Eps15
Yinghui Pu et al.
JOURNAL OF VIROLOGY (2008)
A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication
Kiira Ratia et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Structures of two coronavirus main proteases: Implications for substrate binding and antiviral drug design
Xiaoyu Xue et al.
JOURNAL OF VIROLOGY (2008)
Role of endocytosis and low pH in murine hepatitis virus strain A59 cell entry
Patricia Eifart et al.
JOURNAL OF VIROLOGY (2007)
Structure-based design and synthesis of highly potent SARS-CoV 3CL protease inhibitors
Yi-Ming Shao et al.
CHEMBIOCHEM (2007)
Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus
Chih-Chun Wen et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
Clathrin-dependent entry of severe acute respiratory syndrome coronavirus into target cells expressing ACE2 with the cytoplasmic tail deleted
Yuuki Inoue et al.
JOURNAL OF VIROLOGY (2007)
Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 interaction
Tin-Yun Ho et al.
ANTIVIRAL RESEARCH (2007)
Generation and characterization of human monoclonal neutralizing antibodies with distinct binding and sequence features against SARS coronavirus using XenoMouse®
Melissa Coughlin et al.
VIROLOGY (2007)
Design, synthesis, and evaluation of inhibitors for severe acute respiratory syndrome 3C-like protease based on phthalhydrazide ketones or heteroaromatic esters
Jianmin Zhang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
Ebselen treatment reduces noise induced hearing loss via the mimicry and induction of glutathione peroxidase
Jonathan Kil et al.
HEARING RESEARCH (2007)
Crystal structures reveal an induced-fit binding of a substrate-like aza-peptide epoxide to SARS coronavirus main peptidase
Ting-Wai Lee et al.
JOURNAL OF MOLECULAR BIOLOGY (2007)
Discovering severe acute respiratory syndrome coronavirus 3CL protease inhibitors: Virtual screening, surface plasmon resonance, and fluorescence resonance energy transfer assays
Lili Chen et al.
JOURNAL OF BIOMOLECULAR SCREENING (2006)
Synthesis of glutamic acid and glutamine peptides possessing a trifluoromethyl ketone group as SARS-CoV 3CL protease inhibitors
Magne O. Sydnes et al.
TETRAHEDRON (2006)
Structure-based drug design and structural biology study of novel nonpeptide inhibitors of severe acute respiratory syndrome coronavirus main protease
I-Lin Lu et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Synthesis, crystal structure, structure-activity relationships, and antiviral activity of a potent SARS coronavirus 3CL protease inhibitor
Syaulan Yang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Identification of critical determinants on ACE2 for SARS-CoV entry and development of a potent entry inhibitor
Dong P. Han et al.
VIROLOGY (2006)
Isatin compounds as noncovalent SARS coronavirus 3C-like protease inhibitors
Lu Zhou et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Murine encephalitis caused by HCoV-OC43, a human coronavirus with broad species specificity, is partly immune-mediated
N Butler et al.
VIROLOGY (2006)
Stable benzotriazole esters as mechanism-based inactivators of the severe acute respiratory syndrome 3CL protease
CY Wu et al.
CHEMISTRY & BIOLOGY (2006)
Design and synthesis of dipeptidyl glutaminyl fluoromethyl ketones as potent severe acute respiratory syndrome coronovirus (SARS-CoV) inhibitors
HZ Zhang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Design and biological activities of novel inhibitory peptides for SARS-CoV spike protein and angiotensin-converting enzyme 2 interaction
TY Ho et al.
ANTIVIRAL RESEARCH (2006)
Mechanisms of action of ribavirin against distinct viruses
JD Graci et al.
REVIEWS IN MEDICAL VIROLOGY (2006)
Angiotensin-converting enzyme 2 in lung diseases
Keiji Kuba et al.
CURRENT OPINION IN PHARMACOLOGY (2006)
The papain-like protease of severe acute respiratory syndrome coronavirus has deubiquitinating activity
N Barretto et al.
JOURNAL OF VIROLOGY (2005)
Crystal structures of the main peptidase from the SARS coronavirus inhibited by a substrate-like aza-peptide epoxide
TW Lee et al.
JOURNAL OF MOLECULAR BIOLOGY (2005)
Design and synthesis of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease inhibitors
AK Ghosh et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
A new lead for nonpeptidic active-site-directed inhibitors of the severe acute respiratory syndrome coronavirus main protease discovered by a combination of screening and docking methods
U Kaeppler et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Insights into SARS-CoV transcription and replication from the structure of the nsp7-nsp8 hexadecamer
YJ Zhai et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2005)
Design of wide-spectrum inhibitors targeting coronavirus main proteases
HT Yang et al.
PLOS BIOLOGY (2005)
Structural genomics of the severe acute respiratory syndrome coronavirus:: Nuclear magnetic resonance structure of the protein nsP7
W Peti et al.
JOURNAL OF VIROLOGY (2005)
Structure of SARS coronavirus spike receptor-binding domain complexed with receptor
F Li et al.
SCIENCE (2005)
Inhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic α,β-unsaturated esters
JJ Shie et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2005)
Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry
G Simmons et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Angiotensin-converting enzyme 2 protects from severe acute lung failure
Y Imai et al.
NATURE (2005)
Discovery of potent anilide inhibitors against the severe acute respiratory syndrome 3CL protease
JJ Shie et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Synthesis and evaluation of isatin derivatives as effective SARS coronavirus 3CL protease inhibitors
LR Chen et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2005)
Cinanserin is an inhibitor of the 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro
LL Chen et al.
JOURNAL OF VIROLOGY (2005)
Chloroquine is a potent inhibitor of SARS coronavirus infection and spread
Martin J. Vincent et al.
VIROLOGY JOURNAL (2005)
Severe acute respiratory syndrome related coronavirus is inhibited by interferon-α
U Ströher et al.
JOURNAL OF INFECTIOUS DISEASES (2004)
Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings
CM Chu et al.
THORAX (2004)
Infectious entry of West Nile virus occurs through a clathrin-mediated endocytic pathway
JJH Chu et al.
JOURNAL OF VIROLOGY (2004)
Identification of novel small-molecule inhibitors of severe acute respiratory syndrome-associated coronavirus by chemical genetics
RY Kao et al.
CHEMISTRY & BIOLOGY (2004)
Synthesis and evaluation of keto-glutamine analogues as potent inhibitors of severe acute respiratory syndrome 3CLpro
RP Jain et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Small molecules targeting severe acute respiratory syndrome human coronavirus
CY Wu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide
CJ Wu et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2004)
HIV protease inhibitor nelfinavir inhibits replication of SARS-associated coronavirus
N Yamamoto et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis
I Hamming et al.
JOURNAL OF PATHOLOGY (2004)
In vitro inhibition of severe acute respiratory syndrome coronavirus by chloroquine
E Keyaerts et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
Small molecules blocking the entry of severe acute respiratory syndrome coronavirus into host cells
L Yi et al.
JOURNAL OF VIROLOGY (2004)
High-throughput screening identifies inhibitors of the SARS coronavirus main proteinase
JE Blanchard et al.
CHEMISTRY & BIOLOGY (2004)
Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus
WH Li et al.
NATURE (2003)
The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor
HT Yang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Mechanisms and enzymes involved in SARS coronavirus genome expression
V Thiel et al.
JOURNAL OF GENERAL VIROLOGY (2003)
Treatment of SARS with human interferons
J Cinatl et al.
LANCET (2003)
Interference in Japanese encephalitis virus infection of Vero cells by a cationic amphiphilic drug, chlorpromazine
M Nawa et al.
JOURNAL OF GENERAL VIROLOGY (2003)
Coronavirus main proteinase (3CLpro) structure:: Basis for design of anti-SARS drugs
K Anand et al.
SCIENCE (2003)
The multifunctional or moonlighting protein CD26/DPPIV
E Boonacker et al.
EUROPEAN JOURNAL OF CELL BIOLOGY (2003)
Quantitative mRNA expression profiling of ACE 2, a novel homologue of angiotensin converting enzyme
D Harmer et al.
FEBS LETTERS (2002)
Aza-peptide epoxides: A new class of inhibitors selective for clan CD cysteine proteases
JL Asgian et al.
JOURNAL OF MEDICINAL CHEMISTRY (2002)
Inhibition of endosomal/lysosomal degradation increases the infectivity of human immunodeficiency virus
BL Fredericksen et al.
JOURNAL OF VIROLOGY (2002)
Structure of coronavirus main proteinase reveals combination of a chymotrypsin fold with an extra α-helical domain
K Anand et al.
EMBO JOURNAL (2002)
Pharmacokinetics and safety of an antirhinoviral agent, ruprintrivir, in healthy volunteers
PH Hsyu et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2002)
Functional importance of the coiled-coil of the Ebola virus glycoprotein
S Watanabe et al.
JOURNAL OF VIROLOGY (2000)
Virus-encoded proteinases and proteolytic processing in the Nidovirales
J Ziebuhr et al.
JOURNAL OF GENERAL VIROLOGY (2000)
JC virus enters human glial cells by clathrin-dependent receptor-mediated endocytosis
MT Pho et al.
JOURNAL OF VIROLOGY (2000)