Journal
MEDICAL ENGINEERING & PHYSICS
Volume 84, Issue -, Pages 60-67Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.medengphy.2020.07.013
Keywords
Bone tissue; Implant; Raman spectroscopy; Nanoindentation; Osseointegration
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Funding
- European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program [682001]
- European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant [797764]
- National Science Foundation [DMR 15-07169]
- Marie Curie Actions (MSCA) [797764] Funding Source: Marie Curie Actions (MSCA)
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Titanium implants are widely used in dental and orthopedic surgeries. Osseointegration phenomena lead to direct contact between bone tissue and the implant surface. The quality of the bone-implant interface (BM, resulting from the properties of newly formed bone, determines the implant stability. This study investigates the BII properties using a dedicated in vivo implant model consisting of a coin-shaped Ti-6Al-4V implant inserted in a rabbit femur for 10 weeks. A gap created below the implant was filled with newly formed bone tissue after healing. The properties of mature and newly formed bone tissues were compared using: i) Raman spectroscopy to assess the nanoscale compositional bone properties and ii) nanoindentation to quantify microscale elastic properties in site-matched regions. The mineral-to-matrix ratio, crystallinity (mineral size and lattice order), and the collagen cross-link ratio were significantly lower in newly formed bone tissue (e.g., a mineral-to-matrix ratio of 9.3 +/- 0.5 for proline 853 cm(-1)) compared to mature bone (15.6 +/- 1). Nanoindentation measurements gave Young's modulus of 12.8 +/- 1.8 GPa for newly formed bone and 15.7 +/- 2.3 GPa for mature bone. This multimodal and multiscale approach leads to a better understanding of osseointegration phenomena. (C) 2020 IPEM. Published by Elsevier Ltd. All rights reserved.
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