Journal
MATERIALS TECHNOLOGY
Volume 37, Issue 2, Pages 95-103Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10667857.2020.1816021
Keywords
Linezolid; gelatin nanoparticles; mannosylation; pharmacokinetic; biodistribution; toxicity
Categories
Ask authors/readers for more resources
The present study explores the therapeutic potential of gelatin nanoparticles as a carrier for the delivery of linezolid, a repurposed drug for tuberculosis treatment. The formulation of linezolid loaded mannosylated gelatin nanoparticles showed promising results in reducing the dose, dosing frequency, and toxic adverse effects, ultimately improving patient compliance.
The present study explores the therapeutic potential of gelatin nanoparticles as a carrier for the delivery of linezolid, a repurposed drug for the treatment ofMycobactrium tuberculosis.However, it has significant issues of large dose and toxicity. To overcome this problem, linezolid loaded mannosylated gelatin nanoparticles were prepared for specific targeting to alveolar macrophages. The system was characterised for in-vitro, ex-vivo and in-vivo pharmacokinetics, biodistribution and toxicity studies to evaluate the safety and efficacy of the formulation. The method resulted in small-sized (197-298 nm) nanoparticles with a low polydispersity index (0.127-0.148) and higher drug entrapment (51-56%). The formulation was capable of sustained drug release with a significant increase in mean residence time and the half-life. The system is capable of reducing the dose, dosing frequency, and toxic adverse effects, which ultimately improves patient compliance and, therefore, a promising approach for the effective management of tuberculosis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available