Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 115, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.msec.2020.111116
Keywords
Drug delivery; Thermosensitive liposomes; Doxorubicin; Triggered release; Ultra high field magnetic resonance imaging
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To limit the massive cytotoxicity of chemotherapeutic agents, it is desirable to establish an appropriate subtle blend of formulation design based on a dual-responsive strategy. In this study, a combined therapeutic platform based on magnetic thermosensitive liposomes (Lip(TS-GD)) was developed. The incorporation of chelated-gadolinium imparted magnetic properties to thermosensitive liposomes (Lip(TS)). The application of an ultra high field magnetic resonance imaging (UHF-MRI) induced hyperthermia, thus provided an improved chemotherapeutic effect of Doxorubicin (DOX). The paramagnetic platform demonstrated thermal sensitivity over a narrow temperature range starting at 37.8 degrees C, hence the release of DOX from Lip(TS-GD) can be well triggered by inducing hyperthermia using UHF-MRI application. The prepared Lip(TS-GD) were below 200 nm in diameter and an adequate release of DOX reaching 68% was obtained after 1 h UHF-MRI exposure. Profoundly, triple-negative breast cancer (TNBC) cells that were treated with Lip(TS-GD) and subjected thereafter to UHF-MRI exposure for 60 min showed 36% viability. Hemocompatibility studies of Lip(TS-GD) showed a physiological coagulation time and minimal hemolytic potential. Conclusively, Lip(TS-GD) guided local delivery of DOX to solid tumors will potentially raise the therapeutic index, thus reducing the required dose and frequency of DOX administered systemically without influencing the adjacent tissues.
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