Conifer-like copper-carboxylated graphene nanocomposites modified electrode for sensitive nonenzymatic glucose biosensing with very low limit of detection

A nonenzymatic glucose biosensor based on conifer-like copper-carboxylated graphene nanocomposites modified gold electrode has been developed. Electrochemical detection of glucose by the proposed sen-sors was performed using cyclic voltammetry and chronoamperometry. The proposed electrode exhib-ited good electrocatalytic activity towards glucose oxidation. And the proposed sensors showed excellent performances for glucose detection, including very low limit of detection of 7.96 nM, fast response time of 2 s, wide linear response range from 0.1 mu M to 5.48 mM, high sensitivity of 1142 mu A mM(-1) cm(-2) and good selectivity. Moreover, the proposed sensors could be successfully applied for detec-tion of glucose in human serum. (C) 2020 Elsevier B.V. All rights reserved.