Fabrication of selective L-glutamic acid sensor in electrochemical technique from wet-chemically prepared RuO2 doped ZnO nanoparticles

In this approach, RuO2 doped ZnO nanoparticles (NPs; 10% RuO2 doping) were prepared by wet-chemical method and characterized by powder X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), Energy-dispersive X-ray spectroscopy (EDS), and Field Emission Scanning Electron Microscopy (FESEM). The slurry of RuO2-doped ZnO NPs in ethanol was deposited as thin film of onto a glassy carbon electrode (GCE) to result in a working electrode to be used for L-glutamic acid (L-GA) sensing probe. The electrochemical response of the sensor was found to be linear in the range of 0.1 nM-0.01 mM in current versus logarithm of concentration plot, called 'linear dynamic range (LDR)'. The sensitivity of the electrode is found to be 5.42 mu A mu M-1 cm(-2). The detection limit is estimated to be 96.0 +/- 5.0 pM by using signal-noise ratio of 3. The proposed L-GA sensor has shown excellent reproducibility, good stability and fast response time. It is successfully used to analyze the selective biological sample with the RuO2-doped ZnO nanoparticles fabricated sensor matrix. Thus, this methodology for developing enzyme-less sensor would be the most reliable, efficient, and simple route in the field of healthcare sector in broad scales.