4.7 Article

Bioactive Bianthraquinones and Meroterpenoids from a Marine-Derived Stemphylium sp. Fungus

Journal

MARINE DRUGS
Volume 18, Issue 9, Pages -

Publisher

MDPI
DOI: 10.3390/md18090436

Keywords

bianthraquinones; meroterpenoids; marine-derived fungus; anti-inflammatory activity; Stemphylium sp.

Funding

  1. National Research Foundation (NRF) [2018R1A4A1021703]
  2. Ministry of Science, ICT, & Future Planning, Korea
  3. National Research Foundation of Korea [4199990814417] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

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Three new bianthraquinones, alterporriol Z1-Z3 (1-3), along with three known compounds of the same structural class, were isolated from the culture broth of a marine-derivedStemphyliumsp. fungus. Based upon the results of spectroscopic analyses and ECD measurements, the structures of new compounds were determined to be the 6-6 '- (1and2) and 1-5 '- (3) C-C connectedpseudo-dimeric anthraquinones, respectively. Three new meroterpenoids, tricycloalterfurenes E-G (7-9), isolated together with the bianthraquinones from the same fungal culture broth, were structurally elucidated by combined spectroscopic methods. The relative and absolute configurations of these meroterpenoids were determined by modified Mosher's, phenylglycine methyl ester (PGME), and computational methods. The bianthraquinones significantly inhibited nitric oxide (NO) production and suppressed inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression in LPS-stimulated RAW 264.7 cells.

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