Differentiation of high-grade and low-grade intra-axial brain tumors by time-dependent diffusion MRI

Introduction: Oscillating gradient spin-echo (OGSE) sequences enable acquisitions with shorter diffusion times. There is growing interest in the effect of diffusion time on apparent diffusion coefficient (ADC) values in patients with cancer. However, little evidence exists regarding its usefulness for differentiating between high-grade and low-grade brain tumors. The purpose of this study is to investigate the utility of changes in the ADC value between short and long diffusion times in distinguishing low-grade and high-grade brain tumors. Material and methods: Eleven patients with high-grade brain tumors and ten patients with low-grade brain tumors were scanned using a 3 T magnetic resonance imaging with diffusion-weighted imaging (DWI) using OGSE and PGSE (effective diffusion time [Delta(eff)]: 6.5 ms and 35.2 ms) and b-values of 0 and 1000 s/mm(2). Using a region of interest (ROI) analysis of the brain tumors, we measured the ADC for two Delta(eff) (ADC(Delta eff)) values and computed the subtraction ADC (Delta ADC = ADC(6.5 ms) - ADC(35.2 ms)) and the relative ADC (Delta ADC = (ADC(6.5 ms) - ADC(35.2 ms)) / ADC(35.2 ms) x 100). The maximum values for the subtraction ADC (Delta ADC(max)) and the relative ADC (rADC(max)) on the ROI were compared between low-grade and high-grade tumors using the Wilcoxon rank-sum test. A P-value <.05 was considered significant. The ROIs were also placed in the normal white matter of patients with high- and low-grade brain tumors, and Delta ADC(max) values were determined. Results: High-grade tumors had significantly higher Delta ADC(max )and rADC(max) than low-grade tumors. The Delta ADC(max) values of the normal white matter were lower than the Delta ADC(max) of high- and low-grade brain tumors. Conclusion: The dependence of ADC values on diffusion time between 6.5 ms and 35.2 ms was stronger in high-grade tumors than in low-grade tumors, suggesting differences in internal tissue structure. This finding highlights the importance of reporting diffusion times in ADC evaluations and might contribute to the grading of brain tumors using DWI.