4.7 Article

Neuroactive Peptide Nanofibers for Regeneration of Spinal Cord after Injury

Journal

MACROMOLECULAR BIOSCIENCE
Volume 21, Issue 1, Pages -

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.202000234

Keywords

extracellular matrix; glycosaminoglycan; laminin; peptide nanofibers; spinal cord regeneration

Funding

  1. TUBITAK-BIDEB (2211) Ph.D. fellowship
  2. Science Academy Outstanding Young Scientist Award (BAGEP)

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The study demonstrates the use of peptide nanofibers as a promising approach for stimulating cellular regeneration in spinal cord injuries. These neuroactive nanofibers provide bioactive cues to enable neural regeneration and enhance tissue integrity in both in vitro and in vivo models. Treatment with these peptide nanofiber scaffolds also leads to significant behavioral improvement, suggesting their potential for facilitating regeneration in the white matter of the spinal cord.
The highly complex nature of spinal cord injuries (SCIs) requires design of novel biomaterials that can stimulate cellular regeneration and functional recovery. Promising SCI treatments use biomaterial scaffolds, which provide bioactive cues to the cells in order to trigger neural regeneration in the spinal cord. In this work, the use of peptide nanofibers is demonstrated, presenting protein binding and cellular adhesion epitopes in a rat model of SCI. The self-assembling peptide molecules are designed to form nanofibers, which display heparan sulfate mimetic and laminin mimetic epitopes to the cells in the spinal cord. These neuroactive nanofibers are found to support adhesion and viability of dorsal root ganglion neurons as well as neurite outgrowth in vitro and enhance tissue integrity after 6 weeks of injury in vivo. Treatment with the peptide nanofiber scaffolds also show significant behavioral improvement. These results demonstrate that it is possible to facilitate regeneration especially in the white matter of the spinal cord, which is usually damaged during the accidents using bioactive 3D nanostructures displaying high densities of laminin and heparan sulfate-mimetic epitopes on their surfaces.

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