Journal
LEUKEMIA & LYMPHOMA
Volume 62, Issue 2, Pages 387-398Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10428194.2020.1832662
Keywords
Treatment decision-making; acute myeloid leukemia; older adults; geriatric hematology
Categories
Funding
- National Cancer Institute at the National Institute of Health [UG1 CA189961, K99CA237744]
- National Institute of Aging at the National Institute of Health [K24 AG056589]
- Wilmot Research Fellowship Award
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Treatment decision-making in older patients with AML is influenced by patient-related factors such as comorbidities, functional status, emotional health, cognition, and social factors. Many patients perceive treatment as their only option and feel they have not been offered a choice.
Little is known about the characteristics of patients, physicians, and organizations that influence treatment decisions in older patients with AML. We conducted qualitative interviews with community oncologists and older patients with AML to elicit factors that influence their treatment decision-making. Recruitment was doneviapurposive sampling and continued until theoretical saturation was reached, resulting in the inclusion of 15 patients and 15 oncologists. Participants' responses were analyzed using directed content analysis. Oncologists and patients considered comorbidities, functional status, emotional health, cognition, and social factors when deciding treatment; most oncologists evaluated these using clinical gestalt. Sixty-seven percent of patients perceived that treatment was their only option and that they had not been offered a choice. In conclusion, treatment decision-making is complex and influenced by patient-related factors. These factors can be assessed as part of a geriatric assessment which can help oncologists better determine fitness and guide treatment decision-making.
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