Chalcones and Bis-chalcones Analogs as DPPH and ABTS Radical Scavengers

Background: A number of synthetic scaffolds, along with natural products, have been identified as potent antioxidants. The present study deals with the evaluation of varyingly substituted. medicinally distinct class of compounds chalcones and bis-chalcones for their antioxidant potential. Methods: In vitro radical scavenging activities were performed on a series of synthetic chalcones 1-13 and bis-chalcones 14-18. Results: All molecules 1-18 revealed a pronounced 2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radicals scavenging potential in the ranges of IC50s = 0.58 +/- 0.14 - 1.72 +/- 0.03 and 0.49 +/- 0.3 - 1.48 +/- 0.06 mu M, respectively. Ascorbic acid (IC50s = 0.5 +/- 0.1 and 0.46 +/- 0.17 mu M for DPPH and ABTS, respectively) was used as a standard radical scavenger. Conclusion: Structure-activity relationship (SAR) revealed an active participation of various groups, including -SMe and -OMe in scavenging activity.

Automated summary

The study evaluated the antioxidant potential of synthetic chalcones and bis-chalcones, revealing their significant scavenging activity against DPPH and ABTS radicals. The structure-activity relationship showed the active participation of various groups, such as -SMe and -OMe, in the scavenging activity.