Journal
LANGMUIR
Volume 36, Issue 35, Pages 10321-10330Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.langmuir.0c01018
Keywords
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Funding
- Iran National Science Foundation (INSF) [95841679]
- Institute for Advanced Studies in Basic Sciences (IASBS)
- Center National de la Recherche Scientifique (CNRS)
- University of Lille
- Hauts-de-France region
- CPER Photonics for Society
- Fonds Europeen de Developpement Regional (FEDER)
- CNRS
- Region Nord Pas-de-Calais
- Ministere de l'Education Nationale de l'Enseignement Superieur et de la Recherche
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Given the importance of protein corona in determining cellular esponses to nanoparticles, numerous studies have been devoted to finding stable, biocompatible, and nontoxic protein corona. In this work, the interaction between human alpha-1-acid glycoprotein (AGP) and citrate-stabilized silver (Ag-CIT) nanoparticles of about 10 rim was methodically studied using molecular docking simulation approach and various experimental techniques. It could be shown that a stable Ag-CIT/AGP bioconjugate was formed with a high binding constant of 109 M-1, several orders of magnitude larger than that of other highly abundant serum proteins. Fortnation of AGP corona was accompanied by conserving the native conformation of the protein and further associated with a considerable decrease in the cytotoxicity of the silver nanoparticles.
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