4.2 Article

Hypertrophic gastropathy associated with gastric sarcoma in a dog

Journal

JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION
Volume 33, Issue 1, Pages 112-115

Publisher

SAGE PUBLICATIONS INC
DOI: 10.1177/1040638720966972

Keywords

dogs; hypertrophic gastropathy; Mé né trier-like disease; sarcoma; stomach

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A 14-year-old spayed female Labrador Retriever presented with chronic vomiting, diagnosed with gastric sarcoma which required partial gastrectomy. Pathological examination revealed features of gastric sarcoma, as well as Menetrier-like disease.
A 14-y-old spayed female Labrador Retriever was presented with an 8-mo history of chronic vomiting. Abdominal ultrasound and gastrointestinal endoscopy revealed a mass protruding into the gastric lumen, with cytologic features suggestive of sarcoma. A partial gastrectomy was performed; the gastric body and antrum were thickened, with a cerebriform appearance of the mucosal surface. Histologic examination revealed a submucosal neoplastic proliferation of fusiform cells variably arranged in irregular bundles and scattered whorls. Fusiform cells strongly reacted to antibodies against vimentin, S100, and neuron-specific enolase; glial fibrillary acidic protein was moderately and multifocally expressed. Pancytokeratin, KIT, alpha-smooth muscle actin, and desmin were nonreactive. Histologic and immunohistochemical findings suggested a diagnosis of gastric sarcoma with features referable to a non-GIST (gastrointestinal stromal tumor), non-smooth muscle NIMT (non-angiogenic, non-lymphogenic intestinal mesenchymal tumor). The overlying gastric mucosa was thickened by elongated and dilated gastric glands, predominantly lined by intensely periodic acid-Schiff-stained mucous cells. This altered mucosal architecture was suggestive of Menetrier-like disease. Although this disease has been hypothesized to predispose to gastric adenocarcinoma in dogs, an association with gastric sarcoma has not been documented previously in the veterinary literature, to our knowledge.

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